2-Benzoylpyridine Chemical Properties

Melting point:

41-43 °C (lit.)

Boiling point:

317 °C (lit.)

Density 

1,556 g/cm³

refractive index 

1.5880 (estimate)

Flash point:

302 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

2.90±0.10(Predicted)

form 

Crystalline Chunks

color 

Colorless to slightly yellow

Water Solubility 

insoluble

BRN 

120283

LogP

1.880

CAS DataBase Reference

91-02-1(CAS DataBase Reference)

NIST Chemistry Reference

Methanone, phenyl-2-pyridinyl-(91-02-1)

EPA Substance Registry System

Methanone, phenyl-2-pyridinyl- (91-02-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

OB6400000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29333999

MSDS

• Language:English Provider:Phenyl-2-pyridyl ketone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Benzoylpyridine Usage And Synthesis

Chemical Properties

COLOURLESS TO SLIGHTLY YELLOW CRYSTALLINE CHUNKS

Uses

Organic synthesis.

Uses

2-Benzoylpyridine is used as a reagent to assist crosslinking in acrylic coating compounds in the polymers industry. 2-Benzoylpyridine is also a precursor for thioemicarbazone compounds that exhibit high cytotoxic activity against human leukemia cell lines and also posesses some antiinflammatory qualities.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 1061, 1987 DOI: 10.1002/jhet.5570240429
Tetrahedron Letters, 25, p. 1715, 1984 DOI: 10.1016/S0040-4039(01)81152-7

Purification Methods

Dissolve 2-benzoylpyridine in Et2O, shake it with aqueous NaHCO3, H2O, dry it over MgSO4 and evaporate. The residue solidifies on cooling. The solid can be recrystallised from pet ether. Its hydrochloride crystallises from Me2CO, m 126-127o, and the 2,4-dinitrophenylhydrazone has m 193-195o. It distils at high vacuum. [Kinkerton & Thames J Organomet Chem 24 623 1970, Beilstein 21/8 V 566.]

2-Benzoylpyridine(91-02-1)Related Product Information

• PHENYL VALERATE
• Difenoconazole
• Benzoyl chloride
• 2-Hydroxypyridine
• 2,6-Lutidine
• Sodium benzoate
• Phenylhydrazine
• 1-ISOQUINOLINYL PHENYL KETONE
• 2-Benzoylpyridine oxime ,2-BENZOYLPYRIDINE KETOXIME
• 3-Benzoylpyridine,98+%,3-Benzoylpyridine 97%,3-BENZOYLPYRIDINE
• 1-ETHYL-1,2-DIHYDRO-6-HYDROXY-4-METHYL-2-OXO-3-BENZOYLPYRIDINE
• 4-BENZOYLPYRIDINE,gamma-Benzoylpyridine,4-BENZOYLPYRIDINE 98%,4-Benzoylpyridine99.5%
• 2-(2-AMINO-5-BROMOBENZOYL) PYRIDINE
• 2-Carboxy-3-benzoylpyridine
• (4-CHLOROPHENYL)[3-(1-PYRROLIDINYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE
• (4-CHLOROPHENYL)[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]METHANONE
• 2-BENZOYLPYRIDINE-3-CARBOXYLIC ACID
• 3-AMINO-4-BENZOYLPYRIDINE