D-Glucurone Chemical Properties

Melting point:

172-175 °C (lit.)

alpha 

19 º (c=10, H2O)

Boiling point:

227.71°C (rough estimate)

Density 

1,76 g/cm³

refractive index 

18.5 ° (C=5, H2O)

storage temp. 

Store below +30°C.

solubility 

water: soluble25mg/mL, clear, colorless

form 

Crystals or Crystalline Powder

pka

11.96±0.60(Predicted)

color 

White

Odor

at 100.00 %. very mild mentholic

Odor Type

mentholic

optical activity

[α]24/D +18.8°, c = 8 in H2O

Water Solubility 

SOLUBLE

Merck 

14,4467

BRN 

83595

InChIKey

OGLCQHRZUSEXNB-IEPORWDDSA-N

LogP

-3.457 (est)

CAS DataBase Reference

32449-92-6(CAS DataBase Reference)

EPA Substance Registry System

D-Glucuronolactone (32449-92-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

2

RTECS 

LZ8930000

TSCA 

Yes

HS Code 

29322980

MSDS

• Language:English Provider:D-Glucurone
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D-Glucurone Usage And Synthesis

Chemical Properties

white crystals or crystalline powder

Uses

D-Glucurono-6,3-lactone is a glucuronic acid derivative studied for its effectiveness against canine hepatitis. It is utilized in the studies such as starting regent in the synthesis of 2,3,4,-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, required for the preparation of 1-O-acyl glucuronide of the anti-inflammatory drug ML-3000, synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides.

Uses

D-Glucurone is a glucuronic acid derivative. It is used for treating canine hepatitis.

Definition

The γ-lactone of glucuronic acid. Found in plant gums and animal connective tissues.

General Description

D-(+)-Glucuronic acid γ-lactone (Glucourono-γ-lactone, Glucurone or Glycurone) is a carbohydrate derivative. It converted into L-ascorbic acid in animals and human body. Its molecule contains two five-membered rings. Its crystal structure has been studied.

Purification Methods

Dissolve the lactone or mixture of lactone and acid in H2O and concentrate on a steam bath until crystallisation begins. Cool rapidly to room temperature wih stirring. After 2hours the product is filtered off, washed with cold EtOH and dried to m 174-175o and [] D +19.8o (c 5.2, H2O). The amount of free acid can be obtained by titration of an ice-cold aqueous solution with standard alkali. It can be recrystallised from EtOH, EtOH/H2O or MeOH, and the highest recorded m is 180o. [Stacey J Chem Soc 1529 1939, Mehltretter et al. J Am Chem Soc 73 2424 1951, Beilstein 18 III/IV 3055, 18/5 V 33.]

D-Glucurone(32449-92-6)Related Product Information

• Chlorhexidine digluconate
• SODIUM GLUCOHEPTONATE
• Corn Peptide
• Clotrimazole
• Anise oil
• D-GLUCURONO-1,4-LACTONE,D-GLUCURONO-6,3-LACTONE,D(+)-GLUCURONO-6,3-LACTONE,GLUCURONO-3,6-LACTONE(-D),D-GLUCURONIC ACID LACTONE
• 1,2-O-ISOPROPYLIDENE-ALPHA-D-GLUCURONO-6,3-LACTONE,D-GLUCURONO-6,3-LACTONE ACETONIDE,D-Glucurono-6,3-lactone acetonide, 98+%
• D-Glucuronic acid
• 4-Iodophenol
• D-Glucurone
• Aceglatone
• (S)-(-)-alpha-Hydroxy-gamma-butyrolactone
• L-ERYTHRONO-1,4-LACTONE
• D-LYXONO-1,4-LACTONE
• Glucososamine sulfate
• glucurono-1,4-lactone isonicotinoylhydrazone