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ChemicalBook >  Product Catalog >  Biochemical Engineering >  Condensing agent >  N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate

N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate

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N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate Basic information

Product Name:
N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate
Synonyms:
  • O-(3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIAZIN- 3-YL)-N,N,
  • O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium tetra
  • O-(3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIZIN-3-YL)-N,N,N',N'-TETRAMETHYLURONIUMTETRAFLUOROBORATE
  • TDBTU N,N,N'',N''-TETRAMETHYL-O-(3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIAZIN-3-YL) URONIUMTETRAFLUOROBORATE
  • N,N,N'',N''-TETRAMETHYL-O-(3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIAZIN-3-YL)URONIUM TETRAFLUOROBORATE(TDBTU)
  • 2-(3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIAZIN-3-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE
  • 2-(3,4-DIHYDRO-4-OXO-BENZOTRIAZIN-3-YL)TETRAMETHYLURONIUM TETRAFLUOROBORATE
  • dihydrooxobenzotriazinyl tetramethyluronium fluoroborate
CAS:
125700-69-8
MF:
C12H16BF4N5O2
MW:
349.09
Product Categories:
  • Peptide
  • Peptide Coupling Reagents
  • Coupling Reagent
Mol File:
125700-69-8.mol
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N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate Chemical Properties

Melting point:
147 °C (dec.)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
acetonitrile: 0.1 g/mL, clear
form 
Powder or Solid
color 
White to yellow
Sensitive 
Moisture & Light Sensitive
CAS DataBase Reference
125700-69-8(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
37-36/37/38
Safety Statements 
22-24/25-36-26
RIDADR 
UN 1759 8/PG III
WGK Germany 
3
8-10-21
HazardClass 
8
PackingGroup 
III
HS Code 
29339900

MSDS

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N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate Usage And Synthesis

Chemical Properties

Beige crystalline

Uses

O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N?,N?-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers, condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)2-DAS-(Lys)2 (2,SK&F 107647), coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation.

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