6-QUINOXALINECARBOXYLIC ACID Chemical Properties

Melting point:

224-229 °C (dec.)

Boiling point:

355.1±27.0 °C(Predicted)

Density 

1.421±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Sonicated)

form 

Solid

pka

3.22±0.30(Predicted)

color 

Light Brown to Dark Brown

InChI

InChI=1S/C9H6N2O2/c12-9(13)6-1-2-7-8(5-6)11-4-3-10-7/h1-5H,(H,12,13)

InChIKey

JGQDBVXRYDEWGM-UHFFFAOYSA-N

SMILES

N1C2C(=CC(C(O)=O)=CC=2)N=CC=1

CAS DataBase Reference

6925-00-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

6-QUINOXALINECARBOXYLIC ACID Usage And Synthesis

Chemical Properties

Tan Solid

Uses

6-Quinoxalinecarboxylic Acid is an intermediate used in the production of antiprotozoal agents.

Synthesis

Stage 1: The compound (CAS:131543-46-9) was reacted with 3,4-diaminobenzoic acid in a mixed solvent of ethanol and acetic acid with glyoxal at 75 °C. After completion of the reaction, the resulting suspension was cooled to 5 °C and filtered. The collected wet cake of 6-quinoxaline carboxylic acid was washed with cold ethanol and subsequently dried under vacuum at 50 °C.

References

[1] Patent: US2007/179144, 2007, A1. Location in patent: Page/Page column 5; 6
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 815 - 820
[3] Patent: US2009/286797, 2009, A1. Location in patent: Page/Page column 6
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 14, p. 3771 - 3774
[5] European Journal of Medicinal Chemistry, 2012, vol. 48, p. 255 - 264

6-QUINOXALINECARBOXYLIC ACID(6925-00-4)Related Product Information

• METHYL 6-QUINOXALINECARBOXYLATE
• 6-QUINOXALINECARBONITRILE
• Boronic acid, 6-quinoxalinyl- (9CI)
• QUINOXALINE-6-CARBALDEHYDE
• 6-Quinoxalinepropanoic acid, β-oxo-, ethyl ester
• 3-Quinolinecarboxylic acid
• 2,3-DIMETHYL-6-QUINOXALINECARBOXYLIC ACID
• 3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID 98%,3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID
• 3-Oxo-4H-quinoxaline-2-carboxylic acid,2-Quinoxalinecarboxylic acid, 3,4-dihydro-3-oxo-
• 2-Quinoxalinecarboxylic acid ethyl ester
• 6-Quinoxalinecarboxylic acid, 2,3-dihydro-
• 2-QUINOXALINECARBOXYLIC ACID,2-QUINOXALINECARBOXYLIC ACID (KG LEVEL)
• 2-Quinoxalinecarboxylic acid, 6,7-dihydroxy- (9CI)
• 6-Chloro-2-quinoxalinecarboxylic acid
• 2-Quinoxalinecarboxylic acid methyl ester
• 6-Chloro-2-quinoxalinecarboxylic acid 1,4-dioxide
• 6,7-Dimethyl-3,4-dihydro-3-oxy-2-quinoxalinecarboxylic acid ethyl ester
• 2,3-DIETHYL-QUINOXALINE-6-CARBOXYLIC ACID