AROTINOLOL HCL Chemical Properties

Melting point:

234-235.5° (dec)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

Water Solubility 

Practically insoluble in water

form 

powder to crystal

color 

White to Orange to Green

Merck 

14,791

Safety Information

RIDADR 

UN 2811 6.1/PG III

RTECS 

XM8301000

HS Code 

2934.99.3000

HazardClass 

6.1

PackingGroup 

III

Toxicity

LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara)

AROTINOLOL HCL Usage And Synthesis

Description

Arotinolol hydrochloride i s a β-adrenergic blocker with weak α-antagonistic properties, useful in the treatment of hypertension.

Originator

Sumitomo (Japan)

Uses

Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.

Definition

ChEBI: Arotinolol hydrochloride is an aromatic amide and a member of thiophenes.

Manufacturing Process

To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in 20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol, 12.64 g in 20 ml of methanol was added, while the temperature was maintained at 20°C.
The reaction solution was stirred at room temperature for 4 h, and then condensed to a half volume in vacuo. The residual solution, added with 100 ml of water, was extracted with chloroform. The chloroform extract was washed with water, dried over anhydrous magnesium sulfate and evaporated in vacuo to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'- thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec., recrystallized from methanol/water).
In practice it is usually used as hydrochloride.

brand name

ALMARL

Therapeutic Function

Beta-adrenergic blocker

AROTINOLOL HCL(68377-91-3)Related Product Information

• NADOLOL
• Methimazole
• Benzenesulfonic acid
• Fluvastatin sodium salt
• Alprenolol
• Olmesartan Medoxomil
• AROTINOLOL
• AROTINOLOL HCL
• Almagate
• 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide
• 4-METHYLTHIAZOLE-2-THIOL
• 2-(Aminomethyl)-5-methylthiophene hydrochloride