2-FLUORO-5-HYDROXYPYRIDINE Chemical Properties

Melting point:

148-150°C

Boiling point:

319.8±22.0 °C(Predicted)

Density 

1.325±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

9.03±0.10(Predicted)

color 

White to Almost white

CAS DataBase Reference

55758-32-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

26-36/37/39-39-37

Hazard Note 

Irritant

HS Code 

29339900

2-FLUORO-5-HYDROXYPYRIDINE Usage And Synthesis

Chemical Properties

White fine crystalline powder

Synthesis

5-Acetoxy-2-fluoropyridine (2.26 g, 14.6 mmol, from Step 8d) was used as raw material and dissolved in 20% aqueous NaOH (15 mL). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction solution was neutralized with concentrated HCl. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. Purification by silica gel column chromatography (eluent: CHCl3/MeOH, 98:2) afforded 1.31 g of the target product 2-fluoro-5-hydroxypyridine in 79% yield. Mass spectra (MS) m/z: 114 (M + H)+, 131 (M + NH4)+; 1H NMR (CDCl3, 300 MHz) δ 6.84 (dd, J = 1.85,5.14 Hz, 1H), 7.43 (m, 1H), 7.81 (t, J = 2.84 Hz, 1H).

References

[1] Patent: US6001849, 1999, A
[2] Patent: US6133253, 2000, A

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