8-HYDROXYGUANOSINE CAS#: 3868-31-3

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8-HYDROXYGUANOSINE

Basic information Safety Supplier Related

8-HYDROXYGUANOSINE Basic information

Product Name:

8-HYDROXYGUANOSINE

Synonyms:

8-Oxo-D-guanosine
2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
2-amino-9-beta-d-ribofuranosylpurine-6,8(1h,9h)-dione
7,8-dihydro-8-oxo-guanosin
9h)-dione,2-amino-9-beta-d-ribofuranosyl-purine-8(1h
8-HYDROXYGUANOSINE
8-OHG
8-OH-GUO

CAS:

3868-31-3

MF:

C10H13N5O6

MW:

299.24

Product Categories:

Carbohydrates & Derivatives
Metabolites & Impurities
Nucleotides and Nucleosides
Bases & Related Reagents
Labeling and Diagnostics Reagents
Nucleotides

Mol File:

3868-31-3.mol

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8-HYDROXYGUANOSINE Chemical Properties

Melting point:: 232-235°C
Density: 2.43±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) Water (Slightly, Heated,Sonicated)
form: White to off-white powder.
pka: 7.75±0.20(Predicted)
color: White to Off-White
Stability:: Hygroscopic

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Safety Information

Toxicity: sce-hmn-lym 100 nmol/L MUREAV 403,223,1998

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8-HYDROXYGUANOSINE Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro

Uses

It is a representative metabolite derived by the oxidation of Guanosine (G) and is regarded as a marker of oxidative stress in the cells.

Definition

ChEBI: 8-Hydroxyguanosine is a purine nucleoside.

Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.

in vivo

8-Hydroxyguanosine (60 mg/kg, i.p., 4 h before LPS (1 mg/kg) injected) attenuates the LPS-induced increase in serum levels of TNF-α and IL-18 in LPS-treated mice^[4].

Animal Model:	LPS-treated mice^[4]
Dosage:	60 mg/kg
Administration:	i.p., 4 h before LPS (1 mg/kg) injected
Result:	Attenuated the LPS-induced increase in serum levels of TNF-α and IL-18, but was not significant for IL-6 and IL-12p70 in mice.

IC 50

Human Endogenous Metabolite

8-HYDROXYGUANOSINESupplier

Fuyang Ziyi Biological Pharmaceutical Co., Ltd. Gold

Tel: 19308655899; 19308655899
Email: 2677609105@qq.com

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Email: jkinfo@jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

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Email: 3bsc@sina.com

Hongene Biotech Corporation

Tel: 021-64757213
Email: info@hongene.com

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Email: info@chemlin.com.cn

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