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4'-Methylbiphenyl-2-carboxylic acid

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4'-Methylbiphenyl-2-carboxylic acid Basic information

Product Name:
4'-Methylbiphenyl-2-carboxylic acid
Synonyms:
  • 4'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLIC ACID
  • 2-(4-Methylphenyl)benzoic Acid 4'-Methylbiphenyl-2-carboxylic Acid
  • 2-Carboxy-4'-methylbiphenyl, 2-(4-Methylphenyl)benzoic acid, 2-(p-Tolyl)benzoic acid
  • 2-(p-Tolyl)benzoic Acid
  • 1’-biphenyl]-2-carboxylicacid,4’-methyl-[
  • RARECHEM AL BO 0764
  • 4'-Methyl-2-carboxybiphenyl
  • o-Tolylbenzoic acid
CAS:
7148-03-0
MF:
C14H12O2
MW:
212.24
EINECS:
230-462-0
Product Categories:
  • Organic acids
  • Hypertension
  • INTERMEDIATESOF
  • Biphenyl & Diphenyl ether
  • C13 to C42+
  • Carbonyl Compounds
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Carboxylic Acids
Mol File:
7148-03-0.mol
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4'-Methylbiphenyl-2-carboxylic acid Chemical Properties

Melting point:
146-148°C
Boiling point:
354.5±11.0 °C(Predicted)
Density 
1.156±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
form 
Solid
pka
3.90±0.36(Predicted)
color 
White
CAS DataBase Reference
7148-03-0(CAS DataBase Reference)
EPA Substance Registry System
[1,1'-Biphenyl]-2-carboxylic acid, 4'-methyl- (7148-03-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29163990
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4'-Methylbiphenyl-2-carboxylic acid Usage And Synthesis

Chemical Properties

Light yellow solid

Uses

4’-Methylbiphenyl-2-carboxylic Acid is used in the synthesis of angiotensin II receptor antagonists used as potent orally active antihypertensives.

General Description

4′-Methyl-2-biphenylcarboxylic acid (4′-Methyl-bi-phenyl-2-carboxyl-ic acid) can be synthesized by reacting 4′-methylbiphenyl-2-carbonitrile with methanol and 30% NaOH solution. Its crystal structure has been characterized by the centrosymmetric hydrogen-bonded dimers.

Purification Methods

Crystallise the acid from toluene or *C6H6 (m 147-148o). [Beilstein 9 H 677, 9 IV 2523.]

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