Esomeprazole magnesium trihydrate Chemical Properties

Melting point:

184-189°C (dec.)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Slightly soluble in water, soluble in methanol, practically insoluble in heptane.

form 

Solid

color 

White to off-white

InChI

InChI=1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;

InChIKey

VEVZQDGATGBLIC-UHFFFAOYSA-N

SMILES

C(C1N=CC(C)=C(OC)C=1C)S1C2[N-]C3=CC(OC)=CC=C3N=2[Mg+2]2(O=S(CC3N=CC(C)=C(OC)C=3C)C3[N-]C4=CC(OC)=CC=C4N2=3)O=1.O

CAS DataBase Reference

217087-09-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HS Code 

2933399090

Esomeprazole magnesium trihydrate Usage And Synthesis

Chemical Properties

Off-White Powder

Uses

S-Form of Omeprazole. Gastric proton-pump inhibitor

Uses

Esomeprazole Magnesium Trihydrate is used in preparation of esomeprazole magnesium trihydrate.

Uses

esomeprazole magnesium trihydrate for the healing of peptic ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.

1. Zollinger-Ellison syndrome
2. Peptic ulcer, site unspecified
3. Duodenal ulcer
4. Gastric ulcer
5. Gastro-oesophageal reflux disease

Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). Esomeprazole is registered by the Therapeutic Goods Administration (TGA) for the following indications:

1. Gastro-Oesophageal Reflux Disease (GORD):
2. treatment of erosive reflux oesophagitis;
3. long-term management of patients with healed oesophagitis to prevent relapse;
4. symptomatic treatment of gastro-oesophageal reflux disease (GORD).

In combination with appropriate antibiotics for:

1. healing of duodenal ulcer associated with Helicobacter pylori;
2. eradication of Helicobacter pylori in patients with active or healed peptic ulcer.
3. Short-term treatment of upper gastrointestinal symptoms associated with non-steroidal anti-inflammatory drug (NSAID) (non-selective and COX-2 selective) therapy.
4. Healing of gastric ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
5. Prevention of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy in patients at risk.

brand name

Nexium (AstraZeneca).

Biological Activity

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent, orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release by inhibiting V-H+-ATPases.

in vivo

Esomeprazole magnesium trihydrate(217087-09-7)Related Product Information

• Magnesium sulfate heptahydrate
• Dimethyl sulfoxide
• Magnesium oxide
• Esomeprazole
• Magnesium sulfate
• Esomeprazole magnesium
• (Trifluoromethoxy)benzene
• Benzimidazole
• Dimethyl sulfate
• Dimethyl ether
• Anisole
• Dimethyl carbonate
• Dimethyl fumarate
• Dimethyl phthalate
• ETHANE
• Esomeprazole sodium
• Magnesium stearate
• p-Anisidine
• Esomeprazole Magnesium Trihydrate Usp
• Omeprazole Magnesium Trihydrate