3-Chloro-4-fluoronitrobenzene Chemical Properties

Melting point:

40-42 °C(lit.)

Boiling point:

227-232°C

Density 

1.61

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Light yellow to Green

BRN 

1944997

CAS DataBase Reference

350-30-1(CAS DataBase Reference)

NIST Chemistry Reference

3-Chloro-4-fluoronitrobenzene(350-30-1)

EPA Substance Registry System

3-Chloro-4-fluoronitrobenzene (350-30-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41-36/37/38-20/21/22

Safety Statements 

26-39-36/37/39

RIDADR 

2811

WGK Germany 

3

RTECS 

CZ0720000

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29049090

MSDS

• Language:English Provider:3-Chloro-4-fluoronitrobenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Chloro-4-fluoronitrobenzene Usage And Synthesis

Synthesis

In certain instances, when both chloro and nitro may act as a leaving group, a surprising selectivity of one over the other is observed, for example chloro-2,5- dinitrobenzene was converted to 4-fluoro-3-chloronitrobenzene.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-1-fluoro-4-nitrobenzene is an intermediate used in synthesis of benzoimidolones on Ameba resin and methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate.

Uses

2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:

• benzoimidolones on Ameba resin
• methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Synthetic Communications, 21, p. 505, 1991 DOI: 10.1080/00397919108016776

General Description

2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)₆ and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.

3-Chloro-4-fluoronitrobenzene(350-30-1)Related Product Information

• 4-CHLORO-3-FLUORONITROBENZENE
• 4-(3-Chloropropyl)morpholine
• Isovanillin
• Benzonitrile, 5-methoxy-4-[3-(4-morpholinyl)propoxy]-2-nitro-
• 4-Chloro-3-fluoroaniline
• Benzonitrile, 2-amino-5-methoxy-4-[3-(4-morpholinyl)propoxy]-
• 3-Chloro-2-fluoroaniline
• 4-Fluoronitrobenzene
• Epichlorohydrin
• Cyhalothrin
• Cyhalothrin
• 1-Fluoro-2-nitrobenzene
• 1-Chloro-3-nitrobenzene
• Benzonitrile, 5-hydroxy-4-methoxy-2-nitro-
• 4-Chloronitrobenzene
• Nitrobenzene
• 2-Nitrochlorobenzene
• Difluorochloromethane