Testosterone acetate Chemical Properties

Melting point:

139-141 °C

Boiling point:

427.89°C (rough estimate)

Density 

1.0234 (rough estimate)

refractive index 

1.6000 (estimate)

Flash point:

2℃

storage temp. 

Controlled Substance, -20°C Freezer

solubility 

Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml

form 

A crystalline solid

Water Solubility 

2.35mg/L(25 ºC)

Merck 

13,9255

InChI

InChI=1/C21H30O3/c1-13(22)24-19-7-6-17-16-5-4-14-12-15(23)8-10-20(14,2)18(16)9-11-21(17,19)3/h12,16-19H,4-11H2,1-3H3/t16-,17-,18-,19-,20-,21-/s3

InChIKey

DJPZSBANTAQNFN-PXQJOHHUSA-N

SMILES

[C@]12([H])CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)OC(=O)C |&1:0,4,6,9,11,21,r|

CAS DataBase Reference

1045-69-8(CAS DataBase Reference)

NIST Chemistry Reference

Androst-4-en-3-one, 17-(acetyloxy)-, (17«beta»)-(1045-69-8)

Safety Information

Hazard Codes 

T,Xn,F

Risk Statements 

45-22-63-36-20/21/22-11

Safety Statements 

53-22-26-36-36/37-16

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

XA3061500

MSDS

• Language:English Provider:SigmaAldrich

Testosterone acetate Usage And Synthesis

Description

Testosterone acetate is an analytical reference standard categorized as an anabolic androgenic steroid. It is an ester of the naturally occurring androgen, testosterone. Testosterone acetate is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.

Chemical Properties

White Solid

Uses

Testosterone Acetate is a Controlled substance that is less popular due to Acetate solution, which is aqueous solution, instead of oil solution as other esterified versions of testosterone that is offering much longer half life. It does not have any medical uses when it comes with Acetate ester. However, taken in consideration that it works in the same way as any other esterified testosterone, it can be used for the same purposes as the esterified testosterones.

Definition

ChEBI: Testosterone acetate is an androstanoid that is the acetate derivative of testosterone. It has a role as a human metabolite. It is a sterol ester, an androstanoid and a 3-oxo-Delta(4) steroid. It is functionally related to a testosterone.

Synthesis

A solution of 4.23 g (14.7 mmol) of testosterone in 8 ml of pyridine dried over potassium hydroxide overnight (5 g of KOH to 250 ml of pyridine) is prepared in a 250-ml flask equipped with magnetic stirring. The solution is cooled to 0° C. with a water/ice mixture. 4 ml of acetic anhydride is added to it dropwise. The reaction mixture is left to return to room temperature, and the solution is stirred overnight at RT. After the starting product is no longer found in analytical TLC, 30 ml of distilled water and 30 ml of ethyl acetate are poured into the flask, and the mixture is stirred. The phases are separated with a separating funnel, and the aqueous phase is extracted with 3×20 ml of ethyl acetate. The organic phases are combined, and the solution obtained is washed with 20 nil of distilled water, dried over anhydrous magnesium sulfate, and evaporated in a rotary evaporator. The product thus obtained is dried under reduced pressure using a vacuum pump for 4 hours to remove all the solvents. 4.8 g (yield=99.0%) of testosterone acetate is obtained.

General Description

Testosterone acetate is an androgen ester and an intermediate in the synthesis of testosterone from progesterone, isolated from microorganisms.

Testosterone acetate(1045-69-8)Related Product Information

• Methyl acetate
• 17-Methyltestosterone
• Testosterone undecanoate
• Testosterone
• Sodium acetate
• Potassium Acetate
• Ethyl acetate
• Acetic acid
• Trichloroacetic acid
• Glatiramer acetate
• Testosterone propionate
• Tocopheryl acetate
• Butyl acetate
• Vinyl acetate
• Trifluoroacetic acid
• Testosterone cypionate
• Testosterone enanthate
• Testosterone phenylpropionate