2-Ethylphenol Chemical Properties

Melting point:

-18 °C (lit.)

Boiling point:

195-197 °C (lit.)

Density 

1.037 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.536(lit.)

Flash point:

78 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

pK1:10.2 (25°C)

form 

clear liquid

color 

Colorless to Light yellow

Water Solubility 

insoluble

Merck 

14,3839

BRN 

1099397

Stability:

Stable. Combustible. Incompatible with acid chlorides, acid anhydrides, oxidizing agents.

LogP

2.470

CAS DataBase Reference

90-00-6(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 2-ethyl-(90-00-6)

EPA Substance Registry System

o-Ethylphenol (90-00-6)

Safety Information

Hazard Codes 

Xn,Xi,C

Risk Statements 

22-37/38-41-34-20/21/22

Safety Statements 

36/37/39-45-26

RIDADR 

UN 3145 8/PG 2

WGK Germany 

3

RTECS 

SL4025000

F 

8

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29071900

Hazardous Substances Data

90-00-6(Hazardous Substances Data)

MSDS

• Language:English Provider:2-Ethylphenol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Ethylphenol Usage And Synthesis

Chemical Properties

2-Ethylphenol is a colorless liquid. It is one of three isomeric ethylphenols. It has been used as a reagent for the synthesis of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists for the treatment of diabetes mellitus. 2-Ethylphenol has also been used in the preparation of aminoquinazoline-like toll receptor ligands and for potential immunotherapy.

Uses

2-Ethylphenol is used as a reagent in the synthesis of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists used in the treatment of diabetes. It is also used in the preparation of aminoquinazolines as Toll-like receptor 4 ligands and potential immunotherapeutics.

Definition

ChEBI: 2-Ethylphenol is a member of phenols.

Preparation

2-Ethylphenol is produced by ethylation of phenol using ethylene or ethanol in the presence of aluminium phenolate. It is a natural product found in Cichorium endivia, Saussurea involucrata, and other organisms with data available.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Human toxic action similar to, but less severe than, that of phenol. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. See also PHENOL

Purification Methods

Purify as for p-ethylphenol below. [Beilstein 6 H 470, 6 IV 3011.]

2-Ethylphenol(90-00-6)Related Product Information

• PHENOLDISULFONIC ACID
• 2,4-Dichlorophenol
• Hydroxyethyl Cellulose
• Ethyl cellulose
• Ethyl maltol
• Hydroxyethyl starch
• 4-Aminophenol
• Thymolphthalein Complexone
• Chrysophanic acid
• 1,2,5,8-TETRAHYDROXYANTHRAQUINONE
• Alizarin
• Emodin
• THYMOL BLUE
• 1,8-Dihydroxyanthraquinone
• Alizarin Complexone
• PLUMBAGIN
• Celliton Fast Pink B
• GALVINOXYL