Basic information Uses Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Silane >  Bromotrimethylsilane

Bromotrimethylsilane

Basic information Uses Safety Supplier Related

Bromotrimethylsilane Basic information

Product Name:
Bromotrimethylsilane
Synonyms:
  • TMBS, Trimethylbromosilane, Trimethylsilyl bromide
  • Bromotrimethylsilane Trimethylsilylbromide
  • Bromotrimethylsilane,TMBS, Trimethylbromosilane, Trimethylsilyl bromide
  • Bromotrimethylsilane, AcroSeal, 98%
  • BroMotriMethylsilane, Stab. With Copper Powder or Silver Wire
  • Bromotrimethylsilane,98%
  • Trimethylsilyl bromide, TMBS
  • BroMotriMethylsilane, 98% 100GR
CAS:
2857-97-8
MF:
C3H9BrSi
MW:
153.09
EINECS:
220-672-0
Product Categories:
  • Alkyl Silanes
  • Blocking Agents
  • Protective Agents
  • Silylating Agents
  • Synthetic Organic Chemistry
  • Pharmaceutical Intermediates
  • Si-X (F, Br, I) Compounds
  • Si (Classes of Silicon Compounds)
  • Silicon Compounds (for Synthesis)
Mol File:
2857-97-8.mol
More
Less

Bromotrimethylsilane Chemical Properties

Melting point:
-43 °C
Boiling point:
79 °C(lit.)
Density 
1.16 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.424(lit.)
Flash point:
90 °F
storage temp. 
2-8°C
solubility 
DECOMPOSES
form 
Liquid
color 
Clear colorless to yellow
Specific Gravity
1.1725
Water Solubility 
DECOMPOSES
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
BRN 
1731135
Stability:
Stable. Flammable. Incompatible with strong acids, strong oxidizing agents. May decompose on exposure to water or moist air.
CAS DataBase Reference
2857-97-8(CAS DataBase Reference)
NIST Chemistry Reference
Bromotrimethylsilane(2857-97-8)
EPA Substance Registry System
Silane, bromotrimethyl- (2857-97-8)
More
Less

Safety Information

Hazard Codes 
C
Risk Statements 
10-34-29-14
Safety Statements 
16-26-36/37/39-45-8
RIDADR 
UN 2920 8/PG 2
WGK Germany 
3
10-21
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29310095

MSDS

  • Language:English Provider:TMBS
  • Language:English Provider:SigmaAldrich
  • Language:English Provider:ACROS
  • Language:English Provider:ALFA
More
Less

Bromotrimethylsilane Usage And Synthesis

Uses

Bromotrimethylsilane can protect or deprotect functional groups selectively, act as silane blocking agent, which is widely used in the syntheses of drugs.

Chemical Properties

Clear yellow liquid

Uses

Adefovir intermediate

Uses

Powerful silylating agent

Purification Methods

Purify it by repeated fractional distillation and store it in sealed ampoules in the dark. [McCusker & Reilly J Am Chem Soc 75 1583 1953.] Also fractionate it through a 15-plate column (0.8 x 32cm packed with 1/16in single turn helices of Pt-Ir wire). [Gilliam et al. J Am Chem Soc 68 1161 1946, Pray et al. J Am Chem Soc 70 433 1948, Beilstein 4 IV 4008.]

Bromotrimethylsilane Preparation Products And Raw materials

Raw materials

BromotrimethylsilaneSupplier

Alfa Aesar Gold
Tel
400-610-6006; 021-67582000
Email
saleschina@alfa-asia.com
Yangzhou Sanyou Synthesis Chemical Co., Ltd Gold
Tel
0514-85083918;0514-85083570
Email
sales@upkind.com;sales@upkind.com
Nanjing Vital Chemical Co., Ltd. Gold
Tel
Please Send Email QQ:18652950785
Email
chemweiao@163.com
Shijiazhuang XinZhaoYang Chemical Technology Co., Ltd. Gold
Tel
0311-69032540 13931172911
Email
2636239065@qq.com
Shanghai Darui Fine Chemicals Co., Ltd. Gold
Tel
021-33922791-0
Email
3368239663@qq.com;