Basic information Safety Supplier Related

2-GUANIDINOBENZIMIDAZOLE

Basic information Safety Supplier Related

2-GUANIDINOBENZIMIDAZOLE Basic information

Product Name:
2-GUANIDINOBENZIMIDAZOLE
Synonyms:
  • 2-benzimidazolylguanidine
  • N-1H-benzimidazol-2-ylguanidine hydrate
  • 1-(1H-Benzimidazol-2-yl)guanidine
  • 2-(Diaminomethyleneamino)-1H-benzimidazole
  • AKOS BC-1905
  • 2-GUANIDINOBENZIMIDAZOLE
  • OTAVA-BB BB0111070250
  • TOSLAB-BB TOS-BB-1283
CAS:
5418-95-1
MF:
C8H9N5
MW:
175.19
EINECS:
226-527-8
Product Categories:
  • BENZIMIDAZOLE
  • Benzimidazoles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
Mol File:
5418-95-1.mol
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2-GUANIDINOBENZIMIDAZOLE Chemical Properties

Melting point:
242-244 °C (dec.) (lit.)
Boiling point:
296.48°C (rough estimate)
Density 
1.2954 (rough estimate)
refractive index 
1.6900 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming)
pka
13.67±0.30(Predicted)
form 
solid
color 
Beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference
5418-95-1(CAS DataBase Reference)
EPA Substance Registry System
Guanidine, 1H-benzimidazol-2-yl- (5418-95-1)
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Safety Information

WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933998090

MSDS

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2-GUANIDINOBENZIMIDAZOLE Usage And Synthesis

Description

2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4

Chemical Properties

BROWN-PURPLE FINE CRYSTALLINE POWDER

Uses

N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics.

Definition

ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole.

References

1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077 2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971 3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359 4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673

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