Methylmagnesium chloride Chemical Properties

Boiling point:

66 °C

Density 

1.013 g/mL at 25 °C

Flash point:

−1 °F

storage temp. 

Store below +30°C.

solubility 

Miscible with diethyl ether and tetrahydrofuran.

form 

Liquid

color 

Pale brown to dark green

Water Solubility 

reacts

Sensitive 

Air & Moisture Sensitive

BRN 

3587199

Exposure limits

ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)

CAS DataBase Reference

676-58-4(CAS DataBase Reference)

EPA Substance Registry System

Magnesium, chloromethyl- (676-58-4)

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-14/15-34-19-15-37-14

Safety Statements 

26-30-36/37/39-43-45-7/8-33-29-16

RIDADR 

UN 3399 4.3/PG 2

WGK Germany 

1

F 

1-3-10

Autoignition Temperature

609 °F

TSCA 

Yes

HazardClass 

4.3

PackingGroup 

I

HS Code 

29319090

Hazardous Substances Data

676-58-4(Hazardous Substances Data)

MSDS

• Language:English Provider:Methylmagnesium chloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Methylmagnesium chloride Usage And Synthesis

Chemical Properties

dark brown solution

Uses

Methylmagnesium chloride is used as a Grignard reagent and an alkylating agent in organic synthesis.

Application

Methylmagnesium chloride solution (3 M in THF) undergoes 1,3-addition with dialdose derived nitrones to form N-benzylhydroxylamines. The reductive cleavage of the N-O bond of these N-benzylhydroxylamines results in N-benzylaminosugars, which are key moieties of bioactive compounds. It can also react with Garner type aldehydes to form the corresponding secondary alcohols.

Preparation

reaction of methyl chloride and magnesium in anhydrous diethyl ether, usually in the presence of an initiator.

Definition

ChEBI: Methylmagnesium chloride is an alkylmagnesium halide and a one-carbon compound. available as a solutionin tetrahydrofuran.

Reactions

Methylmagnesium chloride can react with acidic hydrogen on oxygen, sulfur and alkyne carbon of compounds containing active hydrogen (such as water, alcohol, mercaptan, amine, amide, acid, sulfonic acid, etc.); Propyl bromide, etc.) undergoes a coupling reaction; it can react with oxygen and carbon dioxide, aldehydes, ketones, etc.

Hazard

Flammable, dangerous fire and explosionrisk.

Methylmagnesium chloride (676-58-4)Related Product Information

• Polyvinyl chloride
• 2-Methylbenzyl chloride
• Chlorodimethylphenylsilane
• Chloromethane
• TERT-BUTYLMAGNESIUM CHLORIDE
• Vinylmagnesium chloride
• Calcium chloride
• Magnesium chloride
• Ammonium chloride
• Choline chloride
• Pivaloyl chloride
• Acetyl chloride
• Magnesium chloride
• Magnesium chloride hexahydrate
• Potassium chloride
• Methylmagnesium Bromide
• Chloromethyl isopropyl carbonate
• PHENYLMAGNESIUM CHLORIDE