Phenyl carbamate Chemical Properties

Melting point:

149-152 °C(lit.)

Boiling point:

251.96°C (rough estimate)

Density 

1.2528 (rough estimate)

refractive index 

1.5030 (estimate)

storage temp. 

Sealed in dry,Room Temperature

pka

12.33±0.50(Predicted)

Water Solubility 

Soluble in water.

BRN 

2042627

CAS DataBase Reference

622-46-8(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29242998

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Phenyl carbamate Usage And Synthesis

Chemical Properties

white to very slightly pink crystalline flakes

Uses

Phenyl Carbamate is a robust, inert to Pd-catalysis reagent which are useful for arene functionalization/site-selective cross-coupling reactions.

Uses

Phenyl carbamate is used as various phenyl carbamate esters derived from amino acids, a dipeptide and amino acid esters and amides were prepared and assessed as potential prodrugs with the aim of protecting phenolic drugs against first-pass metabolism following per oral administration.

A tin-catalyzed transcarbamoylation of primary and secondary alcohols with phenyl carbamate proceeds smoothly in toluene at 90℃ to generate the corresponding carbamates in good yields. This mild method exhibits a broad functional-group tolerance.
Y. Ichikawa, Y. Morishita, S. Kusaba, N. Sakiyama, Y. Matsuda, K. Nakano, H. Kotsuki, Synlett, 2010, 1815-1818.
http://dx.doi.org/10.1055/s-0030-1258102

Definition

ChEBI: Phenyl carbamate is an aromatic ether.

Phenyl carbamate(622-46-8)Related Product Information

• 2-Benzoxazolinone
• Neostigmine Methyl Sulfate
• Carbofuran
• BDMC
• Neostigmine bromide
• Carbaryl
• Chlorzoxazone
• Phenyl carbamate
• Diphenan
• 3-(Boc-amino)phenylboronic acid pinacol ester, tert-Butyl-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate
• 3-ETHOXYCARBONYLAMINOPHENYL-N-PHENYL-CARBAMATE
• tert-Butyl 2-(aminomethyl)phenylcarbamate
• Retigabine
• Ethyl N-[3-[N'-(3-methylphenyl)carbamoyloxy]phenyl]carbamate
• 2-N-Boc-phenylboronic acid pinacol ester, tert-Butyl-N-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate
• 4-(N-Boc-amino)phenylboronic acid pinacol ester
• (-)-MENTHYL CHLOROFORMATE
• Methyl carbamate