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Phenyl carbamate

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Phenyl carbamate Basic information

Product Name:
Phenyl carbamate
Synonyms:
  • PHENYL CARBAMATE
  • o-Phenyl carbamate
  • Phenyl carbamate,97%
  • Phenylcarbamate,98+%
  • CARBAMICACID,PHENYLESTER
  • Phenyl carbaMate 97%
  • Phenyl carbamate ISO 9001:2015 REACH
CAS:
622-46-8
MF:
C7H7NO2
MW:
137.14
EINECS:
210-737-1
Product Categories:
  • Nitrogen Compounds
  • Organic Building Blocks
  • Protected Amines
Mol File:
622-46-8.mol
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Phenyl carbamate Chemical Properties

Melting point:
149-152 °C(lit.)
Boiling point:
251.96°C (rough estimate)
Density 
1.2528 (rough estimate)
refractive index 
1.5030 (estimate)
storage temp. 
Sealed in dry,Room Temperature
pka
12.33±0.50(Predicted)
Water Solubility 
Soluble in water.
BRN 
2042627
CAS DataBase Reference
622-46-8(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29242998

MSDS

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Phenyl carbamate Usage And Synthesis

Chemical Properties

white to very slightly pink crystalline flakes

Uses

Phenyl Carbamate is a robust, inert to Pd-catalysis reagent which are useful for arene functionalization/site-selective cross-coupling reactions.

Uses

Phenyl carbamate is used as various phenyl carbamate esters derived from amino acids, a dipeptide and amino acid esters and amides were prepared and assessed as potential prodrugs with the aim of protecting phenolic drugs against first-pass metabolism following per oral administration.

A tin-catalyzed transcarbamoylation of primary and secondary alcohols with phenyl carbamate proceeds smoothly in toluene at 90℃ to generate the corresponding carbamates in good yields. This mild method exhibits a broad functional-group tolerance.
Y. Ichikawa, Y. Morishita, S. Kusaba, N. Sakiyama, Y. Matsuda, K. Nakano, H. Kotsuki, Synlett, 2010, 1815-1818.
http://dx.doi.org/10.1055/s-0030-1258102

Definition

ChEBI: Phenyl carbamate is an aromatic ether.

Phenyl carbamate Preparation Products And Raw materials

Preparation Products

Phenyl carbamateSupplier

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