(+/-)-VESAMICOL HYDROCHLORIDE
(+/-)-VESAMICOL HYDROCHLORIDE Basic information
- Product Name:
- (+/-)-VESAMICOL HYDROCHLORIDE
- Synonyms:
-
- AH-5183
- AH-5183 HYDROCHLORIDE
- (+/-)-2-(4-PHENYLPIPERIDINO)CYCLOHEXANOL HYDROCHLORIDE
- (+/-)-VESAMICOL HCL
- (+/-)-VESAMICOL HYDROCHLORIDE
- (+/-)-VESAMICOL HYDROCHLORIDE (AH-5183) >98%
- (±)-2-(4-Phenylpiperidino)cyclohexanol hydrochloride, AH-5183 hydrochloride
- Ah-5183((+/-)-2-(4-phenylpiperidino) cyclohexanol
- CAS:
- 120447-62-3
- MF:
- C17H26ClNO
- MW:
- 295.85
- Mol File:
- 120447-62-3.mol
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(+/-)-VESAMICOL HYDROCHLORIDE Chemical Properties
- storage temp.
- Store at RT
- solubility
- aqueous buffers below pH 8: 1 mM
- form
- solid
- color
- white
MSDS
- Language:English Provider:SigmaAldrich
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(+/-)-VESAMICOL HYDROCHLORIDE Usage And Synthesis
Uses
(+/-)-VesamicolmiddotHCl (AH-5183) is a blocker of acetylcholine transfer into nerve terminal vesicles.
in vivo
(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum[2].
| Animal Model: | Male Wistar rats (120-300 g)[2] |
| Dosage: | 3 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum. |
IC 50
Sigma 1 Receptor; Sigma 2 Receptor
(+/-)-VESAMICOL HYDROCHLORIDESupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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Nanjing Chemlin Chemical Co., Ltd
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Spectrum Chemical Manufacturing Corp.
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Shanghai Beckham Medical Technology Co., Ltd
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Shanghai YuanYe Biotechnology Co., Ltd.
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