6-CHLORO-N-METHYL-NICOTINAMIDE Chemical Properties

Melting point:

152.8-153.4 °C(Solv: dichloromethane (75-09-2))

Boiling point:

347.6±27.0 °C(Predicted)

Density 

1.264±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

13.85±0.46(Predicted)

Appearance

White to light yellow Solid

Safety Information

HS Code 

2933399990

6-CHLORO-N-METHYL-NICOTINAMIDE Usage And Synthesis

Synthesis

a) Preparation of 6-chloro-N-methylnicotinamide: 6-chloro-3-pyridinecarbonyl chloride (5.65 g, 32.1 mmol) was dissolved in tetrahydrofuran (64 mL), and triethylamine (5.59 mL, 40.1 mmol) and tetrahydrofuran solution of methylamine (20.1 mL, 40.1 mmol) were added sequentially, and the reaction was carried out under the condition of ice bath. After addition, the ice bath was withdrawn and the reaction was stirred at room temperature for 3.5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the resulting residue was purified by recrystallization (ethyl acetate/hexane) to afford 6-chloro-N-methyl-nicotinamide (5.06 g, 92% yield) as light brown crystals.1H-NMR (CDCl3) δ: 3.05 (3H, d, J = 4.6 Hz), 6.14 (1H, brs), 7.42 (1H, d, J = 8.3 Hz), 8.09 (1H, dd, J = 2.4, 8.3 Hz), 8.72 (1H, d, J = 2.4 Hz).

References

[1] Patent: US2010/280013, 2010, A1. Location in patent: Page/Page column 13
[2] Patent: US2010/48610, 2010, A1. Location in patent: Page/Page column 22
[3] Patent: US2009/69300, 2009, A1. Location in patent: Page/Page column 28
[4] Patent: WO2005/97778, 2005, A1. Location in patent: Page/Page column 26

6-CHLORO-N-METHYL-NICOTINAMIDE(54189-82-1)Related Product Information

• 2-Chloro-N-methyl-nicotinamide
• 1-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-3-(2,5-DICHLOROPHENYL)IMIDAZOLIDINE-2,4,5-TRIONE
• 6-chloro-N-(4-methylphenyl)pyridine-3-carboxamide
• N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,5-DICHLOROPHENYL)UREA
• N3-PHENYL-6-CHLORONICOTINAMIDE
• 1-[4-(4-CHLOROPHENOXY)PHENYL]-3-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]IMIDAZOLIDINE-2,4,5-TRIONE
• N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(3,4-DICHLOROPHENYL)UREA
• N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,4-DICHLOROPHENYL)UREA
• 1-CHLORO-N-(4-CHLOROPHENYL)-N-METHYL-4-ISOQUINOLINECARBOXAMIDE
• N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(2,6-DICHLOROPHENYL)UREA
• N-[4-(4-CHLOROPHENOXY)PHENYL]-N'-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]UREA
• 1-CHLORO-N-(4-CHLOROPHENYL)-4-ISOQUINOLINECARBOXAMIDE
• N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-(3,5-DICHLOROPHENYL)UREA
• N-(4-CHLOROPHENYL)-N'-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]UREA
• N3-(4-CHLOROPHENYL)-6-CHLORONICOTINAMIDE
• N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-PIPERIDINOUREA
• N3-(2,4-DICHLOROBENZYL)-N3-PROPYL-6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE
• N-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-N'-MORPHOLINOUREA