4-IODO-PYRIDIN-3-OL Chemical Properties

Melting point:

196-200℃

Boiling point:

296.6±20.0 °C(Predicted)

Density 

2.142±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

6.87±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

4-IODO-PYRIDIN-3-OL Usage And Synthesis

Description

4-Iodo-3-hydroxypyridine is an organic intermediate, commonly used in the synthesis of various pharmaceutical and chemical products. It is reported in the literature that 4-iodo-3-hydroxypyridine can be prepared from 2-chloro-4-iodopyridine in one step or from 3-hydroxypyridine in three steps.

Application

4-Iodo-3-hydroxypyridine is an organic intermediate and pharmaceutical intermediate, which is commonly used in the synthesis of various pharmaceutical and chemical products and in laboratory research and development processes.

Synthesis

4-Iodo-3-hydroxypyridine can be prepared by reacting 3-hydroxypyridine, potassium tert-butoxide, and methoxymethyl chloride in a nitrogen atmosphere.

References

[1] Patent: US2010/93720, 2010, A1. Location in patent: Page/Page column 57
[2] Journal of Organic Chemistry, 2005, vol. 70, # 2, p. 489 - 498

4-IODO-PYRIDIN-3-OL(188057-20-7)Related Product Information

• 3-Hydroxy-2-iodo-6-methylpyridine
• 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
• 4-IODO-PYRIDIN-3-OL
• 2-IODO-3-METHOXYPYRIDINE
• 2-Iodo-5-hydroxypyridine
• 2-IODO-3-HYDROXYPYRIDINE
• 5-IODO-PYRIDIN-2-OL
• 3-Hydroxypyridine
• 2,4-Diiodo-3-hydroxypyridine
• 2-iodo-6-methyl-3-pyridinyl methyl ether
• 2,6-Diiodo-3-hydroxypyridine
• 2,4-Diiodo-3-hydroxy-6-methylpyridine
• 5-BROMO-2-IODO-3-METHOXYPYRIDINE
• TERT-BUTYL 4-IODO-5-METHOXYPYRIDIN-3-YLCARBAMATE
• 2-Bromo-4,6-diiodo-3-hydroxypyridine
• 5-BROMO-3-IODO-PYRIDIN-2-OL
• 6-IODO-5-METHOXY-2-PYRIDINECARBOXYLIC ACID
• 2-IODO-3-PYRIDINYL 4-METHOXYBENZENECARBOXYLATE