DIMETHYL-W84 DIBROMIDE Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: soluble; Water: soluble

form 

White to off-white solid.

DIMETHYL-W84 DIBROMIDE Usage And Synthesis

Description

Dimethyl-W84 is a selective allosteric modulator of the M₂ muscarinic acetylcholine receptor. It hinders the dissociation of the orthosteric antagonist N-methylscopolamine from the M₂ receptor with an EC₅₀ value of 3 nM.

Uses

Dimethyl-W84 dibromide is a potent allosteric modulator of muscarinic receptors also selective for M2-receptors.

References

[1] C TR?NKLE. Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors.[J]. Molecular Pharmacology, 1998, 54 1: 139-145. DOI: 10.1124/mol.54.1.139
[2] CHRISTIAN TR?NKLE. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.[J]. Molecular Pharmacology, 2003, 64 1: 180-190. DOI: 10.1124/mol.64.1.180