6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID Chemical Properties

Melting point:

137 °C

Boiling point:

381.2±32.0 °C(Predicted)

Density 

1.404±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

0.96±0.50(Predicted)

Appearance

White to off-white Solid

Safety Information

HazardClass 

IRRITANT

6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of 6-carboxypyridine-2-methanol from ethyl 6-hydroxymethylpyridine-2-carboxylate: ethyl 6-hydroxymethylpyridine-2-carboxylate (200 mg, 1.1 mmol) was dissolved in methanol (1 mL). Subsequently, 2 N NaOH aqueous solution (1 mL) was added slowly and the reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction mixture was acidified to pH=3 with 2 N HCl. The solvent was removed by concentration under reduced pressure, and the residue was dissolved in methanol and filtered. The filtrate was concentrated under reduced pressure to give 6-carboxypyridine-2-methanol (150 mg, 89% yield, white solid).1H NMR (400 MHz, CD3OD) δ: 5.05 (s, 2H), 8.34 (d, J=8.0 Hz, 1H), 8.47 (d, J=8.0 Hz, 1H), 8.73 (d, J=8.0 Hz, 1H).

References

[1] Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1994, vol. 49, # 8, p. 1127 - 1136
[2] Patent: WO2004/113281, 2004, A1. Location in patent: Page 57
[3] Journal of the American Chemical Society, 1982, vol. 104, # 8, p. 2251 - 2257

6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID(1197-10-0)Related Product Information

• THIOSTREPTON
• dimethyl 4-chloropyridine-2,6-dicarboxylate
• Pyridine-2,6-dicarboxylic acid
• Chelidamic acid
• Diethyl 2,6-pyridinedicarboxylate
• Dimethyl 2,6-Pyridinedicarboxylate
• 2,6-Pyridinedicarboxylic acid monomethyl ester
• 4-Pyridoxic acid
• [4,4'-BIPYRIDINE]-2,2',6,6'-TETRACARBOXYLIC ACID TETRAETHYL ESTER
• Ethyl2,6-PyridinedicarboxylateMono
• thiopeptin B
• DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE
• 2,2',6,6'-TETRAKIS(METHOXYCARBONYL)-4,4'-BIPYRIDINE
• siomycin
• 6-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester
• Dimethyl 4-methoxy-2,6-Pyridinedicarboxylate
• Pyridine-2,4,6-tricarboxylic acid
• 4-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester