6-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE Chemical Properties

storage temp. 

2-8°C(protect from light)

Safety Information

HS Code 

2934999090

6-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE Usage And Synthesis

Synthesis

General procedure: Intermediate 13: Synthesis of 6-fluoro-3,4-dihydro-2H-benzo[1,4]oxazine To a stirred mixture of 6-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one (0.9 g, 5.3 mmol) in THF (23 mL) was added dropwise a THF solution of lithium aluminum hydride (6.5 mL, 1 M) at 0 °C to -5 °C. The reaction mixture was stirred for 2 h at room temperature. Subsequently, the mixture was carefully poured onto ice and extracted with ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was ground with ether to give 6-fluoro-3,4-dihydro-2H-benzo[1,4]oxazine (0.5 g, 61% yield) as a dark brown solid. NMR (d6-DMSO) δ: 3.25 (2H, m), 4.05 (2H, m), 6.03 (1H, br s), 6.17 (1H, dt), 6.31 (1H, dd), 6.57 (1H, dd).

References

[1] Archiv der Pharmazie, 2018, vol. 351, # 5,
[2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 32; 33
[3] Patent: US2008/305169, 2008, A1
[4] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 14
[5] Patent: US2007/10670, 2007, A1. Location in patent: Page/Page column 94

6-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE(105655-00-3)Related Product Information

• 6-Fluoro-3,4-dihydro-1,8-naphthyridin-2(1H)-one
• 6,8-DIFLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
• ETHYL 6-FLUORO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLATE
• BUTTPARK 120\07-80
• 6-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
• 6-FLUORO-2-METHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
• 6-FLUORO-2H-1,4-BENZOXAZIN-3(4H)-ONE