7-BROMO-4-CHLOROQUINAZOLINE Chemical Properties

Boiling point:

339.7±22.0 °C(Predicted)

Density 

1.762±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

0.09±0.30(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

T

Risk Statements 

41-25

Safety Statements 

26-39-45

RIDADR 

UN2811

HS Code 

2933599590

7-BROMO-4-CHLOROQUINAZOLINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 7-bromo-4-chloroquinazoline from 7-bromo-3,4-dihydroquinazolin-4-one: 20.4 mL (0.12 mol) of N-ethyl diisopropylamine was added slowly and dropwise to 55.0 g (0.24 mol) of 7-bromo-3H-quinazolin-4-one suspended in 300 mL of phosphorus trichloride. The reaction mixture was stirred at 115 °C for 3 hours and subsequently cooled to room temperature. After conventional post-processing, 48.0 g of the target product 7-bromo-4-chloroquinazoline was obtained as a solid as confirmed by HPLC/MS analysis ([M+H]+ = 244).

References

[1] Patent: US2013/12489, 2013, A1. Location in patent: Paragraph 0183
[2] Patent: WO2010/146173, 2010, A1. Location in patent: Page/Page column 16-17
[3] Patent: WO2005/42498, 2005, A2. Location in patent: Page/Page column 43
[4] Chemical Biology and Drug Design, 2018, vol. 92, # 5, p. 1859 - 1866

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