(1-Methyl-1H-pyrazol-3-yl)methanol Chemical Properties

Boiling point:

243.6±15.0 °C(Predicted)

Density 

1.16±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.61±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

Hazard Note 

Harmful

HS Code 

2933199090

(1-Methyl-1H-pyrazol-3-yl)methanol Usage And Synthesis

Synthesis

General procedure for the synthesis of (1-methyl-1H-pyrazol-3-yl)methanol from methyl 1-methyl-1H-pyrazole-3-carboxylate: lithium aluminium hydride (11.9 g, 314.29 mmol) was added batchwise to methyl 1-methyl-1H-pyrazole-3-carboxylate (22.0 g, 157.14 mmol) in a tetrahydrofuran (150 mL) at 0-5 °C solution. Subsequently, the reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction mixture was cooled to 0 °C using a water/ice bath and 15 mL of water was added to quench the reaction. The resulting solution was diluted with 200 mL of dichloromethane and dried with anhydrous sodium sulfate. After filtration to remove the solid, the mixture was concentrated under vacuum to give (1-methyl-1H-pyrazol-3-yl)methanol as a light yellow liquid (6.0 g, 35% yield).

References

[1] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[2] Journal of the Chemical Society, Chemical Communications, 1985, # 24, p. 1765 - 1766

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