Ethyl 4-bromoacetoacetate Chemical Properties

Boiling point:

231.6 °C

Density 

1.511

refractive index 

1.5281 (estimate)

storage temp. 

2-8°C(protect from light)

pka

9.56±0.46(Predicted)

form 

liquid

color 

Colourless

Safety Information

Hazard Codes 

F

HS Code 

2918300090

Ethyl 4-bromoacetoacetate Usage And Synthesis

Synthesis

To a solution of Ethyl acetoacetate (10.0 g, 76.9 mmol, 1 .0 eq) in acetic acid (30 mL) was added bromine (12.3 g, 76.9 mmol, 1 .0 eq) at 0 °C over 10 min. The mixture was stirred at 0 °C for 1 h, the solvent was removed under reduced pressure, and the residue was diluted with water (50 mL). The aqueous mixture was extracted with CH2CI2 (50 mL x 3). The combined organic layers were washed with brine (60 mL x 2), dried over MgS04 and concentrated under reduced pressure to give ethyl 4-bromo-3-oxobutanoate (14.3 g, 85 per cent) as a yellow oil.

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