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Epitiostanol

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Epitiostanol Basic information

Product Name:
Epitiostanol
Synonyms:
  • 2alpha,3alpha-Epithio-5alpha-androstan-17beta-ol
  • Epithioandrostanol
  • Epitiostanol
  • 10275S
  • 2,3-Epithio-1H-cyclopenta[a]phenanthrene, androstan-17-ol deriv.
  • 2α,3α-Epithio-5α-androstan-17β-ol
  • 5α-Androstan-17β-ol, 2α,3α-epithio- (7CI, 8CI)
  • Androstan-17-ol, 2,3-epithio-, (2α,3α,5α,17β)-
CAS:
2363-58-8
MF:
C19H30OS
MW:
306.51
Product Categories:
  • Inhiitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • Sulfur & Selenium Compounds
Mol File:
2363-58-8.mol
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Epitiostanol Chemical Properties

Melting point:
127-128°
alpha 
D27.5 +24.4° (c = 1.054 in chloroform)
Boiling point:
417.1°C (rough estimate)
Density 
1.0122 (rough estimate)
refractive index 
1.5700 (estimate)
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
15.10±0.60(Predicted)
color 
White to Off-White
Water Solubility 
1.2mg/L(37 ºC)
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Safety Information

Toxicity
LD50 in mice, rats (mg/kg): 1, 5 i.p. (Minesita, p 805)
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Epitiostanol Usage And Synthesis

Originator

Thiodrol,Shionogi,Japan,1977

Uses

An anabolic steroid that exhibits androgenic, myogenic, anabolic, anticatabolic, progestational, deciduomatogenic, and antiestrogenic activities. An anti-estrogen with anti-mammry cancer agent.

Definition

ChEBI: Epitiostanol is an organic molecular entity.

Manufacturing Process

A solution of 2β-thiocyanato-3α-methanesulfonyloxy-5α-androstan-17β-ol 17- acetate (0.82 part by weight) and potassium hydroxide (0.9 part by weight) in diglyme (20 parts by volume) is refluxed on a water bath for 24 hours while stirring. To the reaction mixture, there is added water, and the separated substance is collected by filtration and crystallized from hexane to give 2β,3β- epithio-5α-androstan-17β-ol (0.60 part by weight) as crystals melting at 132.5°C to 134°C.

Therapeutic Function

Antineoplastic

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