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Sophoramine

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Sophoramine Basic information

Product Name:
Sophoramine
Synonyms:
  • SOPHORAMINE96%
  • 11,12,13,14-Tetradehydromatridin-15-one
  • Sophoramine
  • Matridin-15-one, 11,12,13,14-tetradehydro-
  • (4(1)S,7aS,13bS)-2,3,5,6,7,7a,8,13b-octahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(4(1)H)-one
  • 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13b,13c-octahydro-, (7aS,13bS,13cS)-
CAS:
6882-66-2
MF:
C15H20N2O
MW:
244.33
Product Categories:
  • Alkaloids
  • reagent
  • standard substance
Mol File:
6882-66-2.mol
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Sophoramine Chemical Properties

Melting point:
164-5°C
Boiling point:
455.6±34.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
pka
9.67±0.20(Predicted)
NIST Chemistry Reference
Sophoramine(6882-66-2)
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Sophoramine Usage And Synthesis

Description

An alkaloid present in Sophora alopecuroides, the base possesses the tetracyclic structure characteristic of the Sophora alkaloids. It is 1aevorotatory with [α]D - 90.85° or - 98° (EtOH). It yields a series of well crystalline salts and derivatives including the hydrochloride, m.p. 247-8° (dec.); hydriodide, m.p. 294-6°C; aurichloride, m.p. 183-4°C (dec.); p1atinich1oride, m.p. 245-7°C (dec.); picrate, m.p. 229-231°C (dec.) and the picrolonate, m.p. 173-5°C (dec.).

Uses

Sophoramine is a quinolizidine alkaloid isolated from traditional Chinese herbal drugssuch as Sophora flavescens Ait. (Kushen), S. alopecuroides L. (Kudouzi or Kugancao) and S. tonkinensis Gapnep (Shandougen).

Definition

ChEBI: Sophoramine is a naphthyridine derivative.

References

Orekhov., Chern. Zentr., II, 2215 (1935)
Orekhov, Proskurnina, Konovalova., Ber., 68,431 (1935)
Proskurnina, Kuzovkov., Dokl. Akad. Nauk SSSR, 91, 1145 (1953)
Okuda et al., Chern. & Ind., 1326 (1962)

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