Propamidine Chemical Properties

Boiling point:

497.3±55.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

pka

12.75±0.50(Predicted)

Propamidine Usage And Synthesis

Uses

as isethionate.

Definition

ChEBI: A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.

Pharmaceutical Applications

A synthetic diamidine formulated as the isethionate or as dibromopropamidine isethionate for topical administration to the eye. Resistant clinical isolates of Acanthamoeba have been identified. It is available over the counter in eye drops.
Its activity against bacterial pathogens is poor, but it exhibits specific activity against Acanthamoeba spp. Reduction in sensitivity of Acanthamoeba during encystation might reflect changes in drug uptake. It is still recommended for aggressive treatment of amebic keratitis (in combination with neomycin or other agents), but is not well tolerated.

Propamidine(104-32-5)Related Product Information

• DIMETHYL METHOXYMALONATE
• Albendazole
• Propafenone
• Tamoxifen
• (Trifluoromethoxy)benzene
• N,N-Dimethylacetamide
• BENZAMIDINE
• p-Anisaldehyde
• 2-Phenoxyethanol
• 1-Bromopropane
• Epichlorohydrin
• Phenoxybenzamine hydrochloride
• 4-Methoxybenzyl cyanide
• 4-Methoxybenzyl alcohol
• Propylene oxide
• 4-Methoxybenzoyl chloride
• Trimethylolpropane
• Tiopronin