bamifylline hydrochloride Chemical Properties

Melting point:

185-186°

Safety Information

Toxicity

LD50 in mice, rats (mg/kg): 246, 1139 orally; 89, 131 i.p.; 67, 65 i.v. (Georges)

bamifylline hydrochloride Usage And Synthesis

Originator

Bamifylline,ZYF Pharm Chemical

Uses

Bronchodilator.

Manufacturing Process

A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300 L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24 hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture was refluxed. After cooling to the mixture was added the water and hydrochloric acid. The organic phase was extracted with hydrochloric acid. The acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β- hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl- N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol. Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was obtained by addition to the solution the hydrochloric acid; yield 81%, melting point 185-186°C.

Therapeutic Function

Bronchodilator, Coronary vasodilator

bamifylline hydrochloride(20684-06-4)Related Product Information

• bamifylline hydrochloride
• 1-Methylcaffeine
• etamiphyllin
• AC 119
• 8-BENZYLTHEOPHYLLINE
• dimethazan
• BAMIFYLLINE