4-Bromo-1-fluoro-2-iodobenzene Chemical Properties

Boiling point:

247.4±25.0 °C(Predicted)

Density 

2.281

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

form 

liquid

color 

Clear, colourless

Sensitive 

Light Sensitive

InChI

InChI=1S/C6H3BrFI/c7-4-1-2-5(8)6(9)3-4/h1-3H

InChIKey

JNETZJWWXCLUKM-UHFFFAOYSA-N

SMILES

C1(F)=CC=C(Br)C=C1I

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2903998090

4-Bromo-1-fluoro-2-iodobenzene Usage And Synthesis

Chemical Properties

Yellow crstalline

Uses

4-Bromo-1-fluoro-2-iodobenzene is a polyhalogenated benzene derivative containing substitutable reactive groups of fluorine, bromine and iodine atoms in its molecular structure. It is mainly used as a molecular building block, organic synthesis or pharmaceutical intermediate compound, and is a raw material for the preparation of other aromatic alkanes or heterocyclic compounds.

Synthesis

Under argon protection, 5-bromo-2-fluoroaniline (45.6 g, 240 mmol) was dissolved in water (120 mL), stirred and concentrated hydrochloric acid (120 mL) was added slowly. After the reaction mixture was cooled to -20 °C, aqueous sodium nitrite (19.9 g, 288 mmol dissolved in 80 mL of water) was added dropwise. Stirring was continued at -20 °C for 20 min, followed by the addition of aqueous potassium iodide solution (59.8 g, 360 mmol dissolved in 60 mL of water) and stirring was continued for 30 min. After completion of the reaction, the reaction mixture was extracted with hexane and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate and sodium sulfite solutions and dried over anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the residue was purified by silica gel column chromatography to afford 5-bromo-2-fluoroiodobenzene (54.6 g, 181 mmol) in 76% yield.

References

[1] Patent: KR2016/18458, 2016, A. Location in patent: Paragraph 0309-0311
[2] Patent: EP2924029, 2015, A1. Location in patent: Paragraph 0130; 0131

4-Bromo-1-fluoro-2-iodobenzene(116272-41-4)Related Product Information

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