3-FORMYL-1-PHENYL-1H-PYRAZOLE Chemical Properties

Melting point:

60-63 °C(Solv: cyclohexane (110-82-7))

Boiling point:

312.7±15.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-2.33±0.10(Predicted)

form 

solid

color 

white

InChI

InChI=1S/C10H8N2O/c13-8-9-6-7-12(11-9)10-4-2-1-3-5-10/h1-8H

InChIKey

FDKVVJDPHDRHQS-UHFFFAOYSA-N

SMILES

N1(C2=CC=CC=C2)C=CC(C=O)=N1

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-37/39

3-FORMYL-1-PHENYL-1H-PYRAZOLE Usage And Synthesis

Synthesis

At 0°C, 500 mg (2.9 mmol) of (1-phenyl-1H-pyrazol-3-yl)methanol and 0.8 ml (5.7 mmol) of triethylamine were dissolved in 10 ml of dichloromethane and mixed with stirring. 690 mg (4.3 mmol) of pyridine sulfur trioxide was dissolved in 5 ml of dimethyl sulfoxide and this solution was slowly added to the above reaction mixture. After 3 hours of reaction, ethyl acetate was added to the reaction system and subsequently washed with water. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and purified by column chromatography to give 220 mg of 1-phenyl-1H-pyrazole-3-carbaldehyde in 45% yield. The product was characterized as follows: 1H-NMR (CDCl3) δ 9.98 (1H, s), 8.44 (1H, s), 8.17 (1H, s), 7.74-7.71 (2H, m), 7.53-7.49 (2H, m), 7.42-7.38 (1H, m); mass spectrum (EI): m/z 173 (M++1).

References

[1] Patent: WO2005/40127, 2005, A1. Location in patent: Page/Page column 141
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 21, p. 6535 - 6538

3-FORMYL-1-PHENYL-1H-PYRAZOLE(40261-59-4)Related Product Information

• Ethyl 5-amino-4-cyano-1-phenyl-1H-pyrazole-3-carboxylate
• 4,4'-BIS[3-CARBOXY-5-OXO-1-(4-SULFOPHENYL)-2-PYRAZOLIN-4-YL]TRIMETHINE OXONOLE DIPOTASSIUM SALT
• 5-METHYL-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
• 5-METHYL-1-PHENYLPYRAZOLE-3-CARBOXYLIC ACID
• METHYL 1,5-DIPHENYL-1H-PYRAZOLE-3-CARBOXYLATE
• METHYL 3-(2-CHLOROPHENYL)-5-[1-(2,4-DICHLOROPHENYL)-3-(ETHOXYCARBONYL)-1H-PYRAZOL-4-YL]-4-ISOXAZOLECARBOXYLATE
• METHYL 3-(2-CHLORO-6-FLUOROPHENYL)-5-[3-(ETHOXYCARBONYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]-4-ISOXAZOLECARBOXYLATE
• 4-[5-(3-carboxy-5-hydroxy-1-phenyl-1H-pyrazol-4-yl)penta-2,4-dienylidene]-4,5-dihydroxy-5-oxo-1-phenyl-1H-pyrazole-3-carboxylic acid
• 4-[3-[3-carboxy-5-hydroxy-1-(4-sulphophenyl)-1H-pyrazol-4-yl]allylidene]-4,5-dihydro-5-oxo-1-(4-sulphophenyl)-1H-pyrazole-3-carboxylic acid
• METHYL 5-CHLORO-4-[2-(4-METHYLPHENYL)DIAZ-1-ENYL]-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE
• 4-HYDROXY-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
• N'3-(2-CHLOROACETYL)-5-METHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOHYDRAZIDE
• 5-TERT-BUTYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
• METHYL 5-[3-(ETHOXYCARBONYL)-1-(4-METHYLPHENYL)-1H-PYRAZOL-4-YL]-3-PHENYL-4-ISOXAZOLECARBOXYLATE
• DIRECT ORANGE 1
• METHYL 5-[1-(3-CHLOROPHENYL)-3-(ETHOXYCARBONYL)-1H-PYRAZOL-4-YL]-3-(2,6-DICHLOROPHENYL)-4-ISOXAZOLECARBOXYLATE
• METHYL 3-(2-CHLOROPHENYL)-5-[3-(ETHOXYCARBONYL)-1-(4-METHYLPHENYL)-1H-PYRAZOL-4-YL]-4-ISOXAZOLECARBOXYLATE
• METHYL 5-[1-(2-CHLOROPHENYL)-3-(ETHOXYCARBONYL)-1H-PYRAZOL-4-YL]-3-(2,6-DICHLOROPHENYL)-4-ISOXAZOLECARBOXYLATE