Product Identification

Product Name

1,1,1,3,3,3-Hexafluoro-2-propanone

Synonyms

1,1,1,3,3,3-Hexafluoroacetone
2-Propanone, 1,1,1,3,3,3-hexafluoro
Hexafluoro-2-propanone
Perfluoroacetone

CAS

684-16-2

Formula

C3F6O

Molecular Weight

166.03

EINECS

211-676-3

RTECS

UC2450000

RTECS Class

Reproductive Effector

Beilstein/Gmelin

607236

Beilstein Reference

4-01-00-03215

Physical and Chemical Properties

Appearance

Colorless gas. Musty odor becomes acrid in presence of acidic impurities.

Solubility in water

Insoluble

Melting Point

-129

Boiling Point

-26

Vapor Pressure

5010 (25 C)

Density

1.65 g/cm3 (25 C)

Partition Coefficient

1.89

Heat Of Vaporization

22.5 kJ/mol

Usage

Chemical intermediate for hexafluoroisopropanol, polyacrylates for textile coating & polyester coating for textiles, solvent for acetal resins & polyamides, polymer adhesive.

Vapor Density

1.65

First Aid Measures

Ingestion

Administer milk, calcium gluconate, or calcium lactate to bind fluoride ion in the gastrointestinal tract. Antacids (aluminum and/or magnesium based) should be administered. Iv calcium (gluconate or chloride) and magnesium may be necessary to correct serum deficits of these divalent metals in serious overdosage. Monitor ekg and vital signs.

Inhalation

Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.

Skin

Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage

Store in tightly closed container in a cool location.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Ingestion

Epigastric pain, nausea, dysphagia, salivation, hematemesis, and diarrhea may be noted. These effects may be delayed for several hours following exposure. Gi symptoms are noted when 3 to 5 mg/kg of fluoride are ingested.

Inhalation

Respirations are first stimulated then depressed. Death is usually from respiratory paralysis. Following inhalation, coughing and choking may be noted.

Skin

Urticaria and pruritus have been reported following exposure to fluoride.

Eyes

See Skin.

Hazards

Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Containers may explode when heated. Ruptured cylinders may rocket.

EC Risk Phrase

R 14 23/25 37/38 41 44

EC Safety Phrase

S 23 26 36/37/39 45

UN (DOT)

2420

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate protective gloves, clothing and goggles.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Exposure limit(s)

TLV: 0.1 ppm; 0.68 mg/m3 (as TWA) (skin) (ACGIH 1992-1993) NIOSH REL: TWA 0.1 ppm (0.7 mg/m3) skin

Poison Class

3

Fire Fighting Measures

Flash Point

-24

Fire Fighting

Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use alcohol foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources.

Fire Potential

May burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.

Stability and Reactivity

Stability

No data.

Incompatibilities

Reacts with many acids and bases liberating heat and flammable gases (e.g., H2) Reacts with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides Reacts violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Decomposition

Toxic fumes are formed when this material is heated. Reacts with water or acids, producing heat and highly toxic fumes.

Combustion Products

Emits toxic and/or explosive gases under fire conditions.

Transport Information

UN Number

2420

Hazard Class

2.3