ChemicalBook > CAS DataBase List > Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Product Name
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
CAS No.
769195-26-8
Chemical Name
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Synonyms
RETAG-003;Sitagliptin-10;Sitagliptin Impurity 55;Sitagliptin EP Impurity 17;3-oxo-4-(2,4,5-trifluorophenyl;Methyl 3-oxo-4-(2,4,5-trifluorophenyl);Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate;Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate;Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester;2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester
CBNumber
CB01010402
Molecular Formula
C11H9F3O3
Formula Weight
246.19
MOL File
769195-26-8.mol
More
Less

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Property

Melting point:
40-41 °C
Boiling point:
273.3±35.0 °C(Predicted)
Density 
1.330±0.06 g/cm3(Predicted)
refractive index 
1.469
Flash point:
115.5±20.8 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.95±0.46(Predicted)
color 
Pale Yellow to Light Yellow
More
Less

Safety

HS Code 
2918300090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M320785
Product name
Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Packaging
1g
Price
$60
Updated
2021/12/16
TRC
Product number
M320785
Product name
Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Packaging
5g
Price
$110
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0037407
Product name
METHYL 3-OXO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOATE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
60177
Product name
Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Packaging
100g
Price
$950
Updated
2021/12/16
AK Scientific
Product number
Z1749
Product name
Methyl3-oxo-4-(2,4,5-trifluorophenyl)butanoate
Packaging
1g
Price
$104
Updated
2021/12/16
More
Less

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Uses

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.

Preparation

The preparation of methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is as follows:Stage 1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h;Stage 2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h;Stage 3: In acetonitrile at 30℃; for 26h.

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Suppliers

China 140 India 6 United States 10 Global 156
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44700
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9449
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-52878169 15701683040
Email
sales@bjcomparison.com
Country
China
ProdList
4687
Advantage
58
Hunan Furui Biopharma Technology Co., Ltd.
Tel
15902102743
Fax
0731-57805668
Email
shelley@furuipharma.com
Country
China
ProdList
435
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9907
Advantage
55
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Shanghai Micro-Mega Industry Co., Ltd.
Tel
021-34628682 18918069061
Fax
+86 (21) 54285906
Email
sales@micro-megaindustry.com
Country
China
ProdList
95
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Nanjing Redwood Fine Chemical Co., Ltd.
Tel
400-8464006 15805183379
Fax
86-025-58905816
Email
zjp@redwood.com.cn
Country
China
ProdList
645
Advantage
60
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1686
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2031
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9798
Advantage
50
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5941
Advantage
50
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
Country
China
ProdList
4850
Advantage
55
Anqing CHICO Pharmaceutical Co., Ltd.
Tel
13585175604 13585175604
Fax
+86-25-52261140
Email
sales@chicopharm.com
Country
China
ProdList
498
Advantage
65
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q3382968513
Fax
QQ3382968513
Email
hailey@shsendpharm.com
Country
China
ProdList
3151
Advantage
55
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
Email
market@dingdangchem.com
Country
China
ProdList
1748
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
WG reagent
Tel
13391486464
Fax
QQ:14748090
Email
samwjf@163.com
Country
China
ProdList
3090
Advantage
55
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9859
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Shenzhen Sendi Biological Technology Co., Ltd.
Tel
18124570582 TEL：0755-23574479 2355327139
Fax
0755-23229476 QQ: 2355327139
Email
siliao02@yccreate.com
Country
China
ProdList
6120
Advantage
58
Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.
Tel
027-65526929 15102793023
Fax
027-65526669
Email
hbhxry@163.com
Country
China
ProdList
2060
Advantage
55
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
Country
China
ProdList
2718
Advantage
58
Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Fax
028-85255396
Email
cdnovell@163.com
Country
China
ProdList
2251
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15495
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17997
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15503
Advantage
58
Suzhou Liyuan Biomedical Technology Co., Ltd.
Tel
0557-18949975665 18949975665
Email
1184800090@qq.com
Country
China
ProdList
420
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
24971
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10305
Advantage
58
Abydos Scientific
Tel
025-84767922 18936879710
Email
sales@abydoscientific.com
Country
China
ProdList
1029
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52712
Advantage
58
Cool Pharm, Ltd
Tel
18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
13017
Advantage
58
Anhui Feixiang Pharmaceutical Technology Co., Ltd.
Tel
13349001619
Email
sales@feixiangpharm.com
Country
China
ProdList
1008
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55896
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
0755-22202135 13316968096
Email
1979313431@qq.com
Country
China
ProdList
7846
Advantage
58
Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.
Tel
027-027-65385071 17771822910
Fax
027-65526669
Email
2056564811@qq.com
Country
China
ProdList
1752
Advantage
58
Nanjing Asfam Pharmaceutical Technology Co., Ltd.
Tel
025-58867862 18751812725
Fax
02558867862
Email
sales@ace-pharm.com
Country
China
ProdList
1997
Advantage
58
Shanghai Gugang New Materials Technology Co. Ltd.
Tel
021-51317962
Fax
021-51317962
Email
296935822@qq.com
Country
China
ProdList
968
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
2881290884@qq.com
Country
China
ProdList
7506
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
10122
Advantage
58
More
Less

View Lastest Price from Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate manufacturers

Henan Fengda Chemical Co., Ltd
Product
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 769195-26-8
Price
US $0.00/Kg
Min. Order
1Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2023-05-31
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8
Price
US $0.00/Kg
Min. Order
1Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2023-05-31

769195-26-8, Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoateRelated Search:

Sitagliptin (S)-Sitagliptin Phosphate Sitagliptin Impurity 34 Sitagliptin impurity H HCl Sitagliptin Impurity 31 Sitagliptin phosphate (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one Sitagliptin N-Phoshate IMpurity Succinylcholine Chloride Acarbose Ethambutol Paroxetine Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 2,4,5-TRIFLUOROBENZYL CHLORIDE 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate

  • 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
  • 2,4,5-TRIFLUORO-BETA-OXO-BENZENEBUTANOIC ACID METHYL ESTER
  • Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
  • 4-(2,4,5 )triflorophenyl 3-oxobutanoic acid, Methy ester
  • 3-oxo-4-(2,4,5-trifluorophenyl
  • Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester
  • Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate
  • Methyl 3-oxo-4-(2,4,5-trifluorophenyl)
  • RETAG-003
  • Sitagliptin Impurity 55
  • 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
  • Sitagliptin-10
  • 3-oxo-4-(2,4,5-trifluorophenyl)butanoic acid methyl ester
  • Benzenebutanoic acid, 2,4,5-trifluoro-β-oxo-, methyl ester
  • Sitagliptin EP Impurity 17
  • 2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester
  • ethyl (S)-3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
  • 769195-26-8