ChemicalBook > CAS DataBase List > Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Product Name
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
CAS No.
769195-26-8
Chemical Name
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Synonyms
RETAG-003;Sitagliptin-10;Sitagliptin Impurity 55;Sitagliptin EP Impurity 17;3-oxo-4-(2,4,5-trifluorophenyl;Methyl 3-oxo-4-(2,4,5-trifluorophenyl);Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)bu;Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate;Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate;Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester
CBNumber
CB01010402
Molecular Formula
C11H9F3O3
Formula Weight
246.19
MOL File
769195-26-8.mol
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Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Property

Melting point:
40-41 °C
Boiling point:
273.3±35.0 °C(Predicted)
Density 
1.330±0.06 g/cm3(Predicted)
refractive index 
1.469
Flash point:
115.5±20.8 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.95±0.46(Predicted)
color 
Pale Yellow to Light Yellow
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Safety

HS Code 
2918300090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M320785
Product name
Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Packaging
1g
Price
$60
Updated
2021/12/16
TRC
Product number
M320785
Product name
Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Packaging
5g
Price
$110
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0037407
Product name
METHYL 3-OXO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOATE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
60177
Product name
Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Packaging
100g
Price
$950
Updated
2021/12/16
AK Scientific
Product number
Z1749
Product name
Methyl3-oxo-4-(2,4,5-trifluorophenyl)butanoate
Packaging
1g
Price
$104
Updated
2021/12/16
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Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Uses

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.

Preparation

The preparation of methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is as follows:Stage 1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h;Stage 2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h;Stage 3: In acetonitrile at 30℃; for 26h.

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Suppliers

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View Lastest Price from Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate manufacturers

Henan Fengda Chemical Co., Ltd
Product
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 769195-26-8
Price
US $0.00/Kg
Min. Order
1Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2023-05-31
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate 769195-26-8
Price
US $0.00/Kg
Min. Order
1Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2023-05-31

769195-26-8, Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoateRelated Search:

Sitagliptin (S)-Sitagliptin Phosphate Sitagliptin Impurity 34 Sitagliptin impurity H HCl Sitagliptin Impurity 31 Sitagliptin phosphate (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one Sitagliptin N-Phoshate IMpurity Succinylcholine Chloride Acarbose Ethambutol Paroxetine Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 2,4,5-TRIFLUOROBENZYL CHLORIDE 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate

  • 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
  • 2,4,5-TRIFLUORO-BETA-OXO-BENZENEBUTANOIC ACID METHYL ESTER
  • Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
  • 4-(2,4,5 )triflorophenyl 3-oxobutanoic acid, Methy ester
  • 3-oxo-4-(2,4,5-trifluorophenyl
  • Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester
  • Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate
  • Methyl 3-oxo-4-(2,4,5-trifluorophenyl)
  • RETAG-003
  • Sitagliptin Impurity 55
  • 4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
  • Sitagliptin-10
  • 3-oxo-4-(2,4,5-trifluorophenyl)butanoic acid methyl ester
  • Benzenebutanoic acid, 2,4,5-trifluoro-β-oxo-, methyl ester
  • Sitagliptin EP Impurity 17
  • 2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester
  • ethyl (S)-3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
  • Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)bu
  • 769195-26-8