4-(3-fluoro-benzyloxy)-benzaldehyde
- Product Name
- 4-(3-fluoro-benzyloxy)-benzaldehyde
- CAS No.
- 66742-57-2
- Chemical Name
- 4-(3-fluoro-benzyloxy)-benzaldehyde
- Synonyms
- Safinamide Intermediate 1;4-(3-Fluorbenzyloxy)benzaldehyd;Safinamide mesylate Intermediate;Safinamide mesylate Intermediate 1;4-(3-Fluorobenzyloxy)benzaldehyde >4-[(3-fluorophenyl)methoxy]-Benzaldehyde;Benzaldehyde, 4-[(3 -fluorophenyl)Methoxy]-;4-(3-FLUORO-BENZYLOXY)-BENZALDEHYDE Intermediate 1;4-(3-FLUORO-BENZYLOXY)-BENZALDEHYDE ISO 9001：2015 REACH;4-(3-Fluoro-benzyloxy)benzaldehyde, 4-(3-Fluoro- benzyloxy)benzaldehyde
- CBNumber
- CB01010457
- Molecular Formula
- C14H11FO2
- Formula Weight
- 230.23
- MOL File
- 66742-57-2.mol
4-(3-fluoro-benzyloxy)-benzaldehyde Property
- Melting point:
- 46.0 to 50.0 °C
- Boiling point:
- 265°C/3mmHg(lit.)
- Density
- 1.211±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- Solid:crystalline
- color
- White to Almost white
- InChI
- InChI=1S/C14H11FO2/c15-13-3-1-2-12(8-13)10-17-14-6-4-11(9-16)5-7-14/h1-9H,10H2
- InChIKey
- DNKSIIHRKWTIRH-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(OCC2=CC=CC(F)=C2)C=C1
- CAS DataBase Reference
- 66742-57-2
Safety
- HS Code
- 2913.00.4000
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F0943
- Product name
- 4-(3-Fluorobenzyloxy)benzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- F0943
- Product name
- 4-(3-Fluorobenzyloxy)benzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $314
- Updated
- 2025/07/31
- Product number
- F588700
- Product name
- 4-(3-Fluorobenzyloxy)benzaldehyde
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 018793
- Product name
- 4-(3-Fluoro-benzyloxy)-benzaldehyde
- Packaging
- 500mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 018793
- Product name
- 4-(3-Fluoro-benzyloxy)-benzaldehyde
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
4-(3-fluoro-benzyloxy)-benzaldehyde Chemical Properties,Usage,Production
Chemical Properties
4-(3-fluorobenzyloxy)benzaldehyde is white to off-white solid at room temperature and pressure, it is a benzaldehyde derivative, and it is easy to be oxidized by air to produce the corresponding benzoic acid compounds when stored for a long time at room temperature, therefore, it is generally required to be stored under low temperature (2 to 8 degrees).
Uses
4-(3-Fluorobenzyloxy)benzaldehyde is useful for organic reactions and synthesis.
Synthesis
4-(3-fluoro-benzyloxy)-benzaldehyde is synthesized by the reaction of 4-Hydroxybenzaldehyde with 3-fluorobenzyl bromide. 4-Hydroxybenzaldehyde, 3-fluorobenzyl bromide, potassium carbonate, and acetone were sequentially added to a single-neck round bottom flask. Reaction at 60 ° C for 5 h. Cool to room temperature, filter, and collect the filtrate.Purification by direct column chromatography. 4-(3-fluoro-benzyloxy)-benzaldehyde was obtained as a white solid (1.78 g, 94.4%).
References
[1] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 80-81
[2] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 81
[3] Patent: WO2007/147491, 2007, A1. Location in patent: Page/Page column 44-45
[4] Patent: WO2009/74478, 2009, A1. Location in patent: Page/Page column 57-58
[5] Patent: CN106220525, 2016, A. Location in patent: Paragraph 0013; 0014; 0019
4-(3-fluoro-benzyloxy)-benzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(3-fluoro-benzyloxy)-benzaldehyde manufacturers
- Product
- 4-(3-fluoro-benzyloxy)-benzaldehyde 66742-57-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ＞98% by HPLC
- Supply Ability
- 200kg/month
- Release date
- 2023-01-05
- Product
- 4-(3-fluoro-benzyloxy)-benzaldehyde 66742-57-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2021-12-18
- Product
- 4-(3-FLUORO-BENZYLOXY)-BENZALDEHYDE 66742-57-2
- Price
- US $17.00/Kg/Bag
- Min. Order
- 25Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-11-03