Ethyl 5-hydroxynicotinate
- Product Name
- Ethyl 5-hydroxynicotinate
- CAS No.
- 59288-38-9
- Chemical Name
- Ethyl 5-hydroxynicotinate
- Synonyms
- ethyl 5-hydroxynicotinate;3-(Ethoxycarbonyl)-5-hydroxypyridine;ethyl 5-hydroxypyridine-3-carboxylate;Ethyl 5-hydroxy-3-pyridinecarboxylate;5-hydroxy-3-pyridinecarboxylic acid ethyl ester;5-Hydroxypyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 5-hydroxy-, ethyl ester;Ethyl 5-hydroxypyridine-3-carboxylate, 3-(Ethoxycarbonyl)-5-hydroxypyridine
- CBNumber
- CB01010806
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 59288-38-9.mol
Ethyl 5-hydroxynicotinate Property
- Boiling point:
- 375.4±22.0 °C(Predicted)
- Density
- 1.233±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.48±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H9NO3/c1-2-12-8(11)6-3-7(10)5-9-4-6/h3-5,10H,2H2,1H3
- InChIKey
- LFDNUOROKFFJLE-UHFFFAOYSA-N
- SMILES
- C1=NC=C(O)C=C1C(OCC)=O
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-37/39
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- E939788
- Product name
- Ethyl5-Hydroxynicotinate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E13580
- Product name
- 3-(Ethoxycarbonyl)-5-hydroxypyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 8819AB
- Product name
- Ethyl5-hydroxy-3-pyridinecarboxylate
- Packaging
- 10g
- Price
- $274
- Updated
- 2021/12/16
- Product number
- JK157585
- Product name
- 5-Hydroxy-nicotinicacidethylester
- Purity
- 97%
- Packaging
- 1g
- Price
- $316
- Updated
- 2021/12/16
- Product number
- CHM0069807
- Product name
- 5-HYDROXY-NICOTINIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $845.27
- Updated
- 2021/12/16
Ethyl 5-hydroxynicotinate Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Synthesis
27828-71-3
64-17-5
59288-38-9
Stage B: Synthesis of ethyl 5-hydroxynicotinate 1. 2.5 g (18 mmol) of 5-hydroxy-3-pyridinecarboxylic acid prepared in Stage A was dissolved in 50 mL of anhydrous ethanol, and the solution was cooled to 0 °C. 2. 4.4 mL (61 mmol) of thionyl chloride was added slowly dropwise with stirring, taking care to control the rate of dropwise acceleration to avoid violent exotherm. 3. After the dropwise addition, the reaction mixture was heated to reflux and kept for 24 hours. 4. After completion of the reaction, the solvent was removed by evaporation under reduced pressure to obtain the crude product. 5. The crude product was poured into an appropriate amount of ice water, stirred and filtered to collect the solid. 6. 2.5 g (yield: 83%) of ethyl 5-hydroxynicotinate was obtained after drying as a white powder. Product Characterization: - Molecular Formula: C8H9NO3 - Melting point: 150 ℃ - 1H NMR (300 MHz, DMSO-d6) δ (ppm): 8.74 (d, J = 1.2 Hz, 1H), 8.60 (d, J = 2.6 Hz, 1H), 8.07 (m, 1H), 4.44 (q, J = 7.1 Hz, 2H), 1.42 (t, J = 7.1 Hz, 3H) - IR (KBr, cm-1): 3044, 2874, 2677, 1731
References
[1] Patent: WO2006/103120, 2006, A2. Location in patent: Page/Page column 115-116
[2] Patent: CN105418620, 2016, A. Location in patent: Paragraph 0008; 0009
Ethyl 5-hydroxynicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 5-hydroxynicotinate manufacturers
- Product
- Ethyl 5-hydroxynicotinate 59288-38-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5 tons
- Release date
- 2025-03-23