2-Amino-5-Methylthiopyridine
- Product Name
- 2-Amino-5-Methylthiopyridine
- CAS No.
- 77618-99-6
- Chemical Name
- 2-Amino-5-Methylthiopyridine
- Synonyms
- 2-Amino-5-(methylthio);2-Amino-5-Methylthiopyridine;2-Pyridinamine, 5-(methylthio)-;5-methylsulfanylpyridin-2-amine;2-AMino-5-Methylsulfanylpyridine;5-(Methylsulfanyl)-2-pyridinamine
- CBNumber
- CB01013786
- Molecular Formula
- C6H8N2S
- Formula Weight
- 140.21
- MOL File
- 77618-99-6.mol
2-Amino-5-Methylthiopyridine Property
- Melting point:
- 65.5-66.5 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 295.9±20.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 5.52±0.13(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 2168AC
- Product name
- 2-Amino-5-(methylthio)pyridine
- Packaging
- 1g
- Price
- $397
- Updated
- 2021/12/16
- Product number
- CHM0113269
- Product name
- 5-(METHYLSULFANYL)PYRIDIN-2-AMINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $925.31
- Updated
- 2021/12/16
- Product number
- CHM0113269
- Product name
- 5-(METHYLSULFANYL)PYRIDIN-2-AMINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1363.65
- Updated
- 2021/12/16
- Product number
- CHM0113269
- Product name
- 5-(METHYLSULFANYL)PYRIDIN-2-AMINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1759.28
- Updated
- 2021/12/16
- Product number
- 77618996
- Product name
- 2-Amino-5-Methylthiopyridine
- Packaging
- 5g
- Price
- $855.48
- Updated
- 2021/12/16
2-Amino-5-Methylthiopyridine Chemical Properties,Usage,Production
Synthesis
35196-09-9
77618-99-6
The general procedure for the synthesis of 2-amino-5-(methylthio)pyridine from 5-(methylthio)-2-nitropyridine was as follows: 5-(methylthio)-2-nitropyridine (300 mg, 1.8 mmol) was dissolved in a mixed solvent of acetic acid (7 mL) and concentrated hydrochloric acid. Concentrated hydrochloric acid (0.5 mL) and zinc powder (692 mg, 10.6 mmol) were slowly added to the reaction system in batches under ice bath cooling for 5 min. Subsequently, the reaction mixture was stirred at room temperature for 30 min. Upon completion of the reaction, the insoluble material was removed by filtration, and the filtrate was neutralized with aqueous sodium bicarbonate to neutral and extracted with dichloromethane. The organic layers were combined, washed sequentially with water and saturated aqueous sodium chloride, and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the crude product obtained was purified by silica gel column chromatography (elution gradient: hexane/ethyl acetate=1:1→chloroform/methanol=20:1), and finally 158 mg of 2-amino-5-(methylthio)pyridine (Yield 64%) was obtained as a light-yellow powdery crystal.
References
[1] Patent: US6849647, 2005, B1. Location in patent: Page/Page column 145
[2] Patent: US2002/52349, 2002, A1
[3] Patent: US2013/225638, 2013, A1. Location in patent: Paragraph 0282; 0284
2-Amino-5-Methylthiopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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