Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
- Product Name
- Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
- CAS No.
- 3507-27-5
- Chemical Name
- Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
- Synonyms
- 12944-A3;2-chloro-4-methoxybenzothiazle;2-chloro-4-methoxybenzo[d]thiazole;Benzothiazole, 2-chloro-4-Methoxy-;2-chloro-4-methoxy-1,3-benzothiazole - [C71580];Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI)
- CBNumber
- CB01041701
- Molecular Formula
- C8H6ClNOS
- Formula Weight
- 199.66
- MOL File
- 3507-27-5.mol
Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) Property
- Melting point:
- 66 °C
- Boiling point:
- 293.5±13.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.08±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C8H6ClNOS/c1-11-5-3-2-4-6-7(5)10-8(9)12-6/h2-4H,1H3
- InChIKey
- MCCTXJVKIFYBJV-UHFFFAOYSA-N
- SMILES
- S1C2=CC=CC(OC)=C2N=C1Cl
Safety
- HS Code
- 29342000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C376873
- Product name
- 2-chloro-4-methoxy-benzothiazole
- Packaging
- 25mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4291AB
- Product name
- 2-Chloro-4-methoxybenzo[d]thiazole
- Packaging
- 1g
- Price
- $371
- Updated
- 2021/12/16
- Product number
- OR939266
- Product name
- 2-Chloro-4-methoxybenzothiazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $435
- Updated
- 2021/12/16
- Product number
- HCH0049519
- Product name
- 2-CHLORO-4-METHOXYBENZOTHIAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.23
- Updated
- 2021/12/16
- Product number
- 136177
- Product name
- 2-Chloro-4-methoxy-benzothiazole
- Purity
- 95%+
- Packaging
- 1g
- Price
- $524
- Updated
- 2021/12/16
Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Synthesis
5464-79-9
3507-27-5
The general procedure for the synthesis of 2-chloro-4-methoxybenzo[d]thiazole using 2-amino-4-methoxybenzothiazole as starting material was as follows: copper(II) chloride (3.36 g, 25.0 mmol), acetonitrile (71 mL), and isoamyl nitrite (2.2 mL, 16.6 mmol) were added to a 500 mL three-neck flask equipped with a condenser under nitrogen protection. The suspension was placed in a 65 °C oil bath and stirred for 10 min, followed by the slow addition of a solution of 2-amino-4-methoxybenzothiazole (2.00 g, 11.1 mmol) in acetonitrile (42 mL). The reaction mixture was stirred continuously in an oil bath at 65 °C for 2 h and subsequently cooled to 20 °C. Water (150 mL) and 1N hydrochloric acid (100 mL) were added to the reaction mixture, followed by extraction with ethyl acetate (3 x 100 mL). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column chromatography (5% to 15% gradient with ethyl acetate in hexane as eluent) to afford 2-chloro-4-methoxybenzo[d]thiazole (1.52 g, 69% yield) as a white solid.
References
[1] Patent: WO2016/197078, 2016, A1. Location in patent: Paragraph 626
[2] Gazzetta Chimica Italiana, 1964, vol. 94, p. 372 - 381
Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) manufacturers
- Product
- 2-Chloro-4-methoxy-benzothiazole 3507-27-5
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-11
- Product
- Benzothiazole, 2-chloro-4-methoxy- (6CI,7CI,8CI,9CI) 3507-27-5
- Price
- US $1.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-28