1-Methyl-cyclopropanesulfonic acid amide
- Product Name
- 1-Methyl-cyclopropanesulfonic acid amide
- CAS No.
- 669008-26-8
- Chemical Name
- 1-Methyl-cyclopropanesulfonic acid amide
- Synonyms
- EOS-60413;MethylcyclopropylsulfonaMide;1-MethylCyclopropanesulfonaMide;METHYL CYCLOPROPANE SULFONAMIDE;1-Methylcyclopropanesulphonamide;1-METHYL-CYCLOPROPYL SULFONAMIDE;1-Methylcyclopropane-1-sulfonamide;Cyclopropanesulfonamide, 1-methyl-;1-methyl-1-cyclopropanesulfonamide;Cyclopropanesulfomide, 1-methyl- (9CI)
- CBNumber
- CB01051810
- Molecular Formula
- C4H9NO2S
- Formula Weight
- 135.18
- MOL File
- 669008-26-8.mol
1-Methyl-cyclopropanesulfonic acid amide Property
- Melting point:
- 103-104 °C(Solv: hexane (110-54-3))
- Boiling point:
- 246.4±23.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.93±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C4H9NO2S/c1-4(2-3-4)8(5,6)7/h2-3H2,1H3,(H2,5,6,7)
- InChIKey
- ATJVVVCODTXRAE-UHFFFAOYSA-N
- SMILES
- C1(C)(S(N)(=O)=O)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M219405
- Product name
- 1-Methylcyclopropane-1-sulfonamide
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B602
- Product name
- 1-Methylcyclopropane-1-sulfonamide
- Packaging
- 5g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- 076294
- Product name
- 1-Methylcyclopropanesulfonamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $462
- Updated
- 2021/12/16
- Product number
- CHM0093682
- Product name
- 1-METHYL-CYCLOPROPANESULFONIC ACID AMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1085.7
- Updated
- 2021/12/16
- Product number
- 076294
- Product name
- 1-Methylcyclopropanesulfonamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1298
- Updated
- 2021/12/16
1-Methyl-cyclopropanesulfonic acid amide Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Uses
1-Methyl-cyclopropanesulfonic acid amide is a drug that inhibits the activity of serine protease. It has been shown to inhibit the replication of hepatitis C virus and HIV, while also inhibiting the enzymatic activity of human leukocyte elastase.
Biological Activity
1-Methylcyclopropanesulphonamide binds reversibly to the enzyme's active site with an affinity constant (K) of 7 x 10 M at 37°C and pH 7.5 under conditions where the compound exists in its free form or as a protonated molecule.
Synthesis
849022-29-3
669008-26-8
Step 6: Boc-1-methylcyclopropanesulfonamide 2d6 (151.8 mg, 0.65 mmol) was dissolved in dichloromethane (6 mL) and trifluoroacetic acid (6 mL) was added slowly. The reaction mixture was stirred at room temperature for 3.5 hours. Upon completion of the reaction, the solvent was removed by high vacuum evaporation to afford the deprotected product 2d7 as an off-white waxy solid (79.1 mg, 91% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 4.56 (s, 2H), 1.58 (s, 3H), 1.43-1.38 (m, 2H), 0.85-0.80 (m, 2H).
References
[1] Patent: US9527885, 2016, B2. Location in patent: Page/Page column 617
[2] Patent: US9643999, 2017, B2. Location in patent: Page/Page column 68; 69
[3] Patent: WO2006/7700, 2006, A1. Location in patent: Page/Page column 81
[4] Patent: US2006/19905, 2006, A1. Location in patent: Page/Page column 36
[5] Patent: WO2007/9227, 2007, A1. Location in patent: Page/Page column 43
1-Methyl-cyclopropanesulfonic acid amide Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-cyclopropanesulfonic acid amide Suppliers
- Tel
- 28-87999436 02887999436
- Fax
- QQ:2746983436
- sales@sano-chem.com
- Country
- China
- ProdList
- 3795
- Advantage
- 55
- Tel
- 0571-88906230
- Fax
- 0571-88902500
- shenlu@shoufuchem.com
- Country
- China
- ProdList
- 497
- Advantage
- 58
- Tel
- 14782051321
- market@lifebiology.cn
- Country
- China
- ProdList
- 150
- Advantage
- 58
- Tel
- 010-13810111756 13810111756
- Fax
- 13810111756
- 1601345388@qq.com
- Country
- China
- ProdList
- 302
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 025-58395930
- Fax
- 025-5861-9182
- sales@acornpharma.com
- Country
- China
- ProdList
- 982
- Advantage
- 60
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
View Lastest Price from 1-Methyl-cyclopropanesulfonic acid amide manufacturers
- Product
- Cyclopropanesulfonamide, 1-methyl- (9CI) 669008-26-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 1-Methylcyclopropanesulfonamide 669008-26-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.00%
- Supply Ability
- 100tons
- Release date
- 2023-09-25
- Product
- Cyclopropanesulfonamide, 1-methyl- (9CI) 669008-26-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%
- Supply Ability
- 1000kg
- Release date
- 2023-04-05