18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)-
- Product Name
- 18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)-
- CAS No.
- 2376035-98-0
- Chemical Name
- 18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)-
- Synonyms
- -d6 NorgEStrel-d6;Thioctic Acid Impurity 66;D6-Levonorgestrel(D6-D-(-)-Norgestrel);Levonorgestrel-d6 (D-(-)-Norgestrel-d6);18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)-;(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one-2,2,4,6,6,10-d6
- CBNumber
- CB010733796
- Molecular Formula
- C21H28O2
- Formula Weight
- 312.45
- MOL File
- 2376035-98-0.mol
18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)- Property
- solubility
- DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 0.5 mg/ml
- form
- A solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25231
- Product name
- Levonorgestrel-d6
- Purity
- ≥99% deuterated forms (d<sub>1</sub>-d<sub>6</sub>)
- Packaging
- 500 μg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- 25231
- Product name
- Levonorgestrel-d6
- Purity
- ≥99% deuterated forms (d<sub>1</sub>-d<sub>6</sub>)
- Packaging
- 1 mg
- Price
- $362
- Updated
- 2024/03/01
18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)- Chemical Properties,Usage,Production
Description
Levonorgestrel-d6 is intended for use as an internal standard for the quantification of levonorgestrel by GC- or LC-MS. Levonorgestrel is a synthetic progestin and the biologically active component of norgestrel .1 In vivo, levonorgestrel (60 μg/day) suppresses estrus and pregnancy in female cats.2 Post-coital insertion of subdermal levonorgestrel (5 mg pellet) implants prevents uterine implantation of embryos in mice.3 Formulations containing levonorgestrel have been used as contraceptives.
Uses
Norgestrel-d6 is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives. Norgestrel-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
References
1. Jones, R.C., Singer, A.C., and Edgren, R.A. The biological activities of norgestrel and its enantiomers Int. J. Fertil. 24(1),39-43(1979).
2. Baldwin, C.J., Peter, A.T., Bosu, W.T., et al. The contraceptive effects of levonorgestrel in the domestic cat Lab. Anim. Sci. 44(3),261-269(1994).
3. Shirley, B., Bundren, J.C., and McKinney, S. Levonorgestrel as a postcoital contraceptive Contraception 52(2),277-281(1995).
18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)- Preparation Products And Raw materials
Raw materials
Preparation Products
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