4-(Phthalimide)cyclohexanol
- Product Name
- 4-(Phthalimide)cyclohexanol
- CAS No.
- 104618-31-7
- Chemical Name
- 4-(Phthalimide)cyclohexanol
- Synonyms
- 4-(Phthalimide)cyclohexanol;2-(4-Hydroxycyclohexyl)isoindol-1,3-dione;2-(4-Hydroxycyclohexyl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione,2-(4-hydroxycyclohexyl);2-(4-Hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione
- CBNumber
- CB01075076
- Molecular Formula
- C14H15NO3
- Formula Weight
- 245.27
- MOL File
- 104618-31-7.mol
4-(Phthalimide)cyclohexanol Property
- Boiling point:
- 410.1±38.0 °C(Predicted)
- Density
- 1.365
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.99±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- CHM0382883
- Product name
- 4-(PHTHALIMIDE)CYCLOHEXANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.34
- Updated
- 2021/12/16
- Product number
- AA008Y47
- Product name
- 4-(Phthalimide)cyclohexanol
- Purity
- 95%
- Packaging
- 250mg
- Price
- $246
- Updated
- 2021/12/16
- Product number
- CM133673
- Product name
- 2-(4-hydroxycyclohexyl)isoindoline-1,3-dione
- Purity
- 95%+
- Packaging
- 1g
- Price
- $262
- Updated
- 2021/12/16
- Product number
- CD11360370
- Product name
- 2-(4-Hydroxycyclohexyl)isoindoline-1,3-dione
- Purity
- 97%
- Packaging
- 1g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- 104618317
- Product name
- 2-(4-Hydroxycyclohexyl)isoindoline-1,3-dione
- Packaging
- 1g
- Price
- $302.4
- Updated
- 2021/12/16
4-(Phthalimide)cyclohexanol Chemical Properties,Usage,Production
Synthesis
22509-74-6
6850-65-3
104618-31-7
General procedure for the synthesis of 2-(4-hydroxycyclohexyl)isoindole-1,3-dione from N-ethoxycarbonylphthalimide and 4-aminocyclohexanol: 4-aminocyclohexanol (2.627 g, 22.81 mmol) and 1,3-dioxo-1,3-dihydroisoindole-2-carboxylic acid ethyl ester (5 g, 22.81 mmol) were placed in large test tubes using a heat gun until both were completely melted and continued heating for 5 minutes. After completion of the reaction, the resulting solution was allowed to cool to room temperature and a solid was formed. The solid product was transferred to a flask, dissolved in dichloromethane (CH2Cl2) and purified by column chromatography (75% ethyl acetate/hexane) to afford 4.57 g of 2-(4-hydroxycyclohexyl)isoindole-1,3-dione in 81% yield.LCMS (m/z): [M+H+MeCN]+ = 287.1.
References
[1] Patent: US2008/269193, 2008, A1. Location in patent: Page/Page column 33
[2] Patent: WO2013/13188, 2013, A1. Location in patent: Paragraph 00486
[3] Patent: US9416132, 2016, B2. Location in patent: Page/Page column 183; 184
[4] Journal of medicinal chemistry, 1993, vol. 36, # 13, p. 1918 - 1919
4-(Phthalimide)cyclohexanol Preparation Products And Raw materials
Raw materials
Preparation Products
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