ChemicalBook > CAS DataBase List > 1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-

Product Name
1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-
CAS No.
2259624-71-8
Chemical Name
1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-
Synonyms
C53;LZAP;MST016;PP1553;OK/SW-cl.114;STING agonist C53;STING activator Compound 53;STING activator Compound 53, 10 mM in DMSO;Recombinant Human CDK5RAP3 protein (His Tag);1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide
CBNumber
CB010785689
Molecular Formula
C25H19ClF4N2O2
Formula Weight
490.88
MOL File
2259624-71-8.mol
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1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Property

Boiling point:
628.4±55.0 °C(Predicted)
Density 
1.392±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO : 250 mg/mL (509.29 mM; Need ultrasonic)
form 
A crystalline solid
pka
13.31±0.40(Predicted)
color 
Light yellow to yellow
SMILES
O=C(C1=CC=C2C(N(CC3=C(Cl)C=CC=C3F)C(C2(C)C)=O)=C1)NCC4=C(F)C=C(F)C=C4F
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML4208
Product name
STING agonist C53
Purity
≥98% (HPLC), powder, STING agonist
Packaging
5 mg
Price
$79
Updated
2026/03/19
Sigma-Aldrich
Product number
SML4208
Product name
STING agonist C53
Purity
≥98% (HPLC), powder, STING agonist
Packaging
25 mg
Price
$319
Updated
2026/03/19
Sigma-Aldrich
Product number
SML4208
Product name
STING agonist C53
Purity
≥98% (HPLC)
Packaging
1 unit
Price
$79
Updated
2025/07/31
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1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Chemical Properties,Usage,Production

Uses

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1].

Biological Activity

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1]. STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].STING agonist-12 is not active at mouse STING[1]. STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1].

in vivo

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1].

Animal Model:Balb/c mice (n=3)[1]
Dosage:5 or 10 mpk
Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)
Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse[1].
RouteDOSE
(mpk)		AUC
(ng/mL*h) 		T1/2
(h)		Cmax
(ng/mL)		Vd
(mL/kg)		F
(%)
IV512151.4118672689NA
PO102090NA1723NA86

storage

Store at -20°C

References

[1]. Pryde DC, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869.

1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- Suppliers

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2259624-71-8, 1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-Related Search:


  • 1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-
  • STING activator Compound 53
  • 1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide
  • Inhibitor,HEK293T,STING agonist-12,MPYS,STING agonist12,STING,STING agonist 12,STING activator Compound 53,TMEM173,inhibit,ERIS,Stimulator of Interferon Genes,MITA
  • C53
  • 1-[(2-chloro-6-fluoro-phenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]indoline-6-carboxamide
  • 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide
  • STING agonist C53
  • STING activator Compound 53, 10 mM in DMSO
  • LZAP
  • MST016
  • OK/SW-cl.114
  • PP1553
  • Recombinant Human CDK5RAP3 protein (His Tag)
  • 2259624-71-8