1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI)
- Product Name
- 1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI)
- CAS No.
- 628732-03-6
- Chemical Name
- 1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI)
- Synonyms
- 7-Aminoindan-1-one;7-Amino-1-indanone;dihydroinden-7-aMino-2,3-dihydro- (9CI);7-aMino-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one,7-amino-2,3-dihydro-;7-Amino-2,3-dihydroinden-1-one - [A9496];1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI);1-(2-nitrophenyl)-3-(prop-1-en-2-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
- CBNumber
- CB01087583
- Molecular Formula
- C9H9NO
- Formula Weight
- 147.17
- MOL File
- 628732-03-6.mol
1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI) Property
- Boiling point:
- 325.8±31.0 °C(Predicted)
- Density
- 1.254±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.43±0.20(Predicted)
- Appearance
- Yellow to orange Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FA161226
- Product name
- 7-Aminoindan-1-one
- Packaging
- 100mg
- Price
- $172
- Updated
- 2021/12/16
- Product number
- FA161226
- Product name
- 7-Aminoindan-1-one
- Packaging
- 250mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- Y5493
- Product name
- 7-Amino-2,3-dihydroinden-1-one
- Packaging
- 1g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- CHM0101754
- Product name
- 7-AMINO-2,3-DIHYDROINDEN-1-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.58
- Updated
- 2021/12/16
- Product number
- FA161226
- Product name
- 7-Aminoindan-1-one
- Packaging
- 500mg
- Price
- $510
- Updated
- 2021/12/16
1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI) Chemical Properties,Usage,Production
Synthesis
58161-36-7
628732-03-6
General procedure for the synthesis of 7-amino-2,3-dihydro-1-indenone from N-(3-oxo-2,3-dihydro-1H-inden-4-yl)acetamide: N-(3-oxo-2,3-dihydro-1H-inden-4-yl)acetamide (12.4 g, 0.065 mol) was dissolved in 6 N hydrochloric acid (150 mL), heated to 90 °C and the reaction was maintained for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of raw materials, the reaction mixture was cooled to room temperature. Subsequently, sodium carbonate (Na2CO3) was added in batches and the pH was adjusted dropwise to 8 by adding 2 M sodium hydroxide (NaOH) solution. the aqueous phase was extracted with ethyl acetate (EtOAc), the organic phases were combined, and dried over anhydrous sodium sulfate (Na2SO4). The organic phase was concentrated under reduced pressure to give 7-amino-2,3-dihydro-1-indanone (9.4 g, 98% yield) as a brown solid, which could be used for the subsequent reaction without further purification. m/z = 148.1 [M + H]+ by LC-MS.
References
[1] Patent: WO2006/21544, 2006, A1. Location in patent: Page/Page column 36-37
[2] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 629; 631
[3] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10195 - 10198
[4] Patent: CN103848811, 2016, B. Location in patent: Paragraph 0413; 0414; 0415; 0416
[5] Patent: CN103709163, 2016, B. Location in patent: Paragraph 0158-0160
1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI) manufacturers
- Product
- 1H-Inden-1-one, 7-amino-2,3-dihydro- (9CI) 628732-03-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13