4-Methylquinolin-8-ol

Product Name: 4-Methylquinolin-8-ol
CAS No.: 3846-73-9
Chemical Name: 4-Methylquinolin-8-ol
Synonyms: 8-Hydroxylepidine;4-Methylquinolin-8-o;4-Methylquinolin-8-ol;4-Methyl-8-quinolinol;8-Quinolinol, 4-Methyl-;4-METHYL-8-HYDROXYQUINOLINE;8-hydroxy-4-methylquinoline
CBNumber: CB01089411
Molecular Formula: C10H9NO
Formula Weight: 159.18
MOL File: 3846-73-9.mol

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4-Methylquinolin-8-ol Property

Melting point:: 141 °C(Solv: water (7732-18-5); ethanol (64-17-5))
Boiling point:: 330.0±22.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: pK1:5.56(＋1);pK2:10.00(0) (25°C)
Appearance: Light green to green Solid

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M337460
Product name: 4-Methylquinolin-8-ol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR916329
Product name: 4-Methyl-8-hydroxyquinoline
Purity: 95%
Packaging: 1g
Price: $445
Updated: 2021/12/16

Apolloscientific

Product number: OR916329
Product name: 4-Methyl-8-hydroxyquinoline
Purity: 95%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0151461
Product name: 8-HYDROXY-4-METHYLQUINOLINE
Purity: 95.00%
Packaging: 1G
Price: $1097.25
Updated: 2021/12/16

AK Scientific

Product number: V2266
Product name: 8-Hydroxy-4-methylquinoline
Packaging: 5g
Price: $1545
Updated: 2021/12/16

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4-Methylquinolin-8-ol Chemical Properties,Usage,Production

Synthesis

78-94-4

95-55-6

3846-73-9

37% hydrochloric acid (45.5 mL) and o-aminophenol (10.91 g, 0.1 mol) were added to a 250 mL two-necked round-bottomed flask, stirred thoroughly and heated to 120 °C. Methyl vinyl ketone (14.32 mL, 0.175 mol) was added slowly and the reaction was kept at reflux for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was neutralized with aqueous sodium hydroxide. Subsequently, extraction was performed with dichloromethane (50 mL × 3). The organic phases were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using dichloromethane as eluent. Finally, the solvent mixture of dichloromethane and hexane (1:1, v/v) was used to recrystallize to give 4-methyl-8-hydroxyquinoline (4.38 g, 27.5% yield) as a colorless solid. The NMR hydrogen spectrum (400 MHz, (CD3)2CO, Me4Si) data were as follows: δ 8.68 (d, 1H, J = 4.4 Hz), 7.55 (dd, 1H, J1 = 8.4 Hz, J2 = 1.5 Hz), 7.51 (dd, 1H, J1 = 8.4 Hz, J2 = 7.2 Hz), 7.41 (dd, 1H, J1 = 4.4 Hz, J2 = 0.8 Hz), 7.12 (dd, 1H, J1 = 7.2 Hz, J2 = 1.5 Hz), 2.71 (d, 3H, J = 0.8 Hz).

References

[1] Chemical Communications, 2015, vol. 51, # 84, p. 15458 - 15461
[2] Journal of the Chinese Chemical Society, 2004, vol. 51, # 4, p. 735 - 742
[3] Tetrahedron Letters, 2016, vol. 57, # 25, p. 2797 - 2799
[4] Journal of the American Chemical Society, 1949, vol. 71, p. 3986
[5] Patent: US4843082, 1989, A

4-Methylquinolin-8-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methylquinolin-8-ol Suppliers

China 62 India 1 Switzerland 1 United States 5 Global 69

Shandong Xiya Chemical Co., Ltd

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Chengdu HuaXia Chemical Reagent Co. Ltd

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Shanghai HuanChuan Industry Co.,Ltd.

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View Lastest Price from 4-Methylquinolin-8-ol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Methylquinolin-8-ol 3846-73-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-12

Career Henan Chemical Co

Product: 4-Methylquinolin-8-ol 3846-73-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-14

3846-73-9, 4-Methylquinolin-8-olRelated Search:

4-Methylquinolin-8-ol 4-QUINOLINECARBOXYLIC ACID,8-METHOXY-2-PHENYL- 2-chloro-5,8-dimethoxy-4-methylquinoline OTAVA-BB BB7020204772 TRIS(4-METHYL-8-HYDROXYQUINOLINE)ALUMINUM 2-HYDROXY-4-METHYL-8-METHOXYQUINOLINE 8-hydroxyquinoline-4-carboxylic acid 6,8-DIMETHOXY-4-METHYLQUINOLINE BUTTPARK 123\40-59 (8-METHOXY-4-METHYL-QUINOLIN-2-YLSULFANYL)-ACETIC ACID BUTTPARK 53\40-48 2-(2-hydroxy-5-n-hexylphenyl)-8-quinolinol-4-carboxylic acid 2-METHYL-4-PHENYL-8-QUINOLINOL BUTTPARK 123\40-58 BUTTPARK 53\40-50 4-HYDROXYMETHYL-QUINOLIN-8-OL BUTTPARK 123\40-57 BUTTPARK 113\40-40

4-Methyl-8-quinolinol

8-Hydroxylepidine

4-Methylquinolin-8-o

8-Quinolinol, 4-Methyl-

8-hydroxy-4-methylquinoline

4-METHYL-8-HYDROXYQUINOLINE

4-Methylquinolin-8-ol

3846-73-9

Electronic Chemicals