5-(tert-Butyl)-1H-imidazole-4-carbaldehyde
- Product Name
- 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde
- CAS No.
- 714273-83-3
- Chemical Name
- 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde
- Synonyms
- EOS-62086;5-(tert-Butyl)imidazole-4-carbaldehyde;4-tert-butyl-1H-iMidazole-5-carbaldehyde;5-tert-butyl-3H-imidazole-4-carbaldehyde;Ethyl-5-(tert-butyl)oxazote-4-carboxylate;1H-Imidazole-4-carbaldehyde,5-(1,1-dimethylethyl)-;5-(1,1-Dimethylethyl)-1H-imidazole-4-carboxaldehyde;1H-Imidazole-5-carboxaldehyde, 4-(1,1-dimethylethyl)-;1H-IMidazole-4-carboxaldehyde, 5-(1,1-diMethylethyl)-;1H-Imidazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)- (9CI)
- CBNumber
- CB01089729
- Molecular Formula
- C8H12N2O
- Formula Weight
- 152.19
- MOL File
- 714273-83-3.mol
5-(tert-Butyl)-1H-imidazole-4-carbaldehyde Property
- Boiling point:
- 338.9±30.0 °C(Predicted)
- Density
- 1.092±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 11.53±0.10(Predicted)
- form
- solid
- color
- Off-white
- InChI
- InChI=1S/C8H12N2O/c1-8(2,3)7-6(4-11)9-5-10-7/h4-5H,1-3H3,(H,9,10)
- InChIKey
- FSTXHTKEZGSDNN-UHFFFAOYSA-N
- SMILES
- C1NC(C=O)=C(C(C)(C)C)N=1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4H15-1-3F
- Product name
- 5-tert-Butyl-1H-imidazole-4-carbaldehyde
- Packaging
- 250mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- 0197DA
- Product name
- 5-(Tert-Butyl)-1H-imidazole-4-carbaldehyde
- Packaging
- 1g
- Price
- $258
- Updated
- 2021/12/16
- Product number
- OR303275
- Product name
- 5-tert-Butyl-1H-imidazole-4-carbaldehyde
- Purity
- 95%
- Packaging
- 500mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- 4H15-1-3F
- Product name
- 5-tert-Butyl-1H-imidazole-4-carbaldehyde
- Packaging
- 500mg
- Price
- $317
- Updated
- 2021/12/16
- Product number
- OR303275
- Product name
- 5-tert-Butyl-1H-imidazole-4-carbaldehyde
- Purity
- 95%
- Packaging
- 250mg
- Price
- $211
- Updated
- 2021/12/16
5-(tert-Butyl)-1H-imidazole-4-carbaldehyde Chemical Properties,Usage,Production
Synthesis
51721-22-3
714273-83-3
General procedure for the synthesis of 5-(tert-butyl)-1H-imidazole-4-carbaldehyde from (5-tert-butyl-1H-imidazol-4-yl)methanol: 50 g (324 mmol) of 5-(tert-butyl)-1H-imidazole-4-methanol was dissolved in 500 mL of dichloromethane, and 282 g (3242 mmol) of manganese dioxide was added as oxidizer. The reaction mixture was stirred at room temperature for 24 hours to complete the oxidation reaction. Upon completion of the reaction, solid impurities were removed by filtration with the aid of diatomaceous earth. The filter cake was washed three times (500 mL each) with anhydrous ethanol to remove residual reactants and by-products. Finally, the filtrate was concentrated under reduced pressure to give 43 g of a light yellow solid product, 5-(tert-butyl)-1H-imidazole-4-carbaldehyde, in 87% yield.
References
[1] Patent: CN107011331, 2017, A. Location in patent: Paragraph 0045; 0046
[2] Patent: CN107011322, 2017, A. Location in patent: Paragraph 0026; 0029
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1056 - 1071
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 6, p. 1416 - 1419
5-(tert-Butyl)-1H-imidazole-4-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde manufacturers
- Product
- 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde 714273-83-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-10
- Product
- 1H-Imidazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)- (9CI) 714273-83-3
- Price
- US $10.00/KG
- Min. Order
- 25Kg/Drum
- Purity
- 99.99%
- Supply Ability
- 20 tons/month
- Release date
- 2021-04-20
- Product
- 1H-Imidazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)- (9CI) 714273-83-3
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-07