(6-Chloro-pyridin-2-yl)-acetonitrile
- Product Name
- (6-Chloro-pyridin-2-yl)-acetonitrile
- CAS No.
- 75279-60-6
- Chemical Name
- (6-Chloro-pyridin-2-yl)-acetonitrile
- Synonyms
- 6-Chloro-2-pyridineacetonitrile;2-Pyridineacetonitrile, 6-chloro-;2-(6-chloropyridin-2-yl)acetonitrile;(6-Chloro-pyridin-2-yl)-acetonitrile;2-(6-chloro-2-pyridinyl)acetonitrile
- CBNumber
- CB01112980
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 75279-60-6.mol
(6-Chloro-pyridin-2-yl)-acetonitrile Property
- Boiling point:
- 270.7±25.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -1.57±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
N-Bromosuccinimide Price
- Product number
- C596265
- Product name
- 2-(6-Chloropyridin-2-yl)acetonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Y6377
- Product name
- (6-Chloro-pyridin-2-yl)-acetonitrile
- Packaging
- 1g
- Price
- $317
- Updated
- 2021/12/16
- Product number
- Y6377
- Product name
- (6-Chloro-pyridin-2-yl)-acetonitrile
- Packaging
- 10g
- Price
- $986
- Updated
- 2021/12/16
- Product number
- 75279606
- Product name
- 2-Chloropyridine-6-acetonitrile
- Packaging
- 10g
- Price
- $1068.12
- Updated
- 2021/12/16
- Product number
- CM171018
- Product name
- 2-(6-Chloropyridin-2-yl)acetonitrile
- Purity
- 95%
- Packaging
- 25g
- Price
- $1122
- Updated
- 2021/12/16
(6-Chloro-pyridin-2-yl)-acetonitrile Chemical Properties,Usage,Production
Uses
2-(6-Chloropyridin-2-yl)acetonitrile is a useful research chemical used in the cyanomethylation of bromopyridines by nucleophilic substitution with lithioacetonitrile.
Synthesis
2402-78-0
75-05-8
75279-60-6
Under argon protection, acetonitrile (2.77 mL) was dissolved in tetrahydrofuran (80 mL) and cooled to -78 °C. A hexane solution of n-butyllithium (1.6 M, 29.6 mL) was added slowly and the reaction mixture was stirred at -78 °C for 1 hour. Subsequently, a solution of tetrahydrofuran (10 mL) of 2,6-dichloropyridine (2.0 g) was added dropwise at the same temperature and stirring was continued at -78 °C for 2 hours. Upon completion of the reaction, the mixture was allowed to slowly warm up to room temperature. Water was added to the reaction mixture and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to give 6-chloro-2-pyridine acetonitrile (1.91 g). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 3.93 (2H, s), 7.33 (1H, dd, J = 8.1, 0.6 Hz), 7.43 (1H, dd, J = 7.5, 0.6 Hz), 7.73 (1H, t, J = 7.8 Hz).
References
[1] Synlett, 2000, # 10, p. 1488 - 1490
[2] Patent: EP2818473, 2014, A1. Location in patent: Paragraph 0676
(6-Chloro-pyridin-2-yl)-acetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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