ChemicalBook > CAS DataBase List > (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL

Product Name
(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL
CAS No.
127733-40-8
Chemical Name
(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL
Synonyms
S-MBT-PEM;(S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(S)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANAMINE;(S)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine;(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H;(S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-amine;(S)-ALPHA-METHYL-BIS-3,5-TRIFLUOROMETHYLBENZYLAMINE;(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL;(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethan-1-amine
CBNumber
CB0111302
Molecular Formula
C10H9F6N
Formula Weight
257.18
MOL File
127733-40-8.mol
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(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL Property

Boiling point:
60/14mm
Density 
1.327±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
8.39±0.10(Predicted)
CAS DataBase Reference
127733-40-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
Hazard Note 
Irritant
HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T897653
Product name
(S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine
Packaging
50mg
Price
$130
Updated
2021/12/16
SynQuest Laboratories
Product number
3830-3-S1
Product name
(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine
Purity
97%
Packaging
1g
Price
$195
Updated
2021/12/16
SynQuest Laboratories
Product number
3830-3-S1
Product name
(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine
Purity
97%
Packaging
100mg
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
3830-3-S1
Product name
(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine
Purity
97%
Packaging
250mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
132400
Product name
(S)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethanaminehydrochloride
Purity
97%
Packaging
1g
Price
$900
Updated
2021/12/16
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(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL Chemical Properties,Usage,Production

Uses

(R)-1-(3,5-Bis(Trifluoromethyl)phenyl)ethanamine Hydrochloride is a useful reactant for the preparation of palladium complexes with chiral pincer ligands.

Synthesis

384824-41-3

511256-29-4

127733-40-8

127733-47-5

The general procedure for the synthesis of (S)-1 -[3,5-bis(trifluoromethyl)phenyl]ethylamine and (R)-1 -[3,5-bis(trifluoromethyl)phenyl]ethylamine, using compound (CAS:384824-41-3) and compound (CAS:511256-29-4) as raw materials, is as follows: 181 mg (0.5 mmol) of the optically active crude product of secondary amine (4a) with 18 mg (0.25 wt%) of 5% palladium/activated carbon (water content: 50 wt%) was added to 2 mL of ethanol. Subsequently, the hydrogen pressure was set to 0.2 MPa and the reaction was stirred at 55°C for 12 hours. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth, the filtrate was concentrated and dried under vacuum to afford 96 mg of the crude product, i.e., optically active 1-(3,5-bis(trifluoromethyl)phenyl)ethylamine (5a), in 75% yield. The conversion was determined to be 99% by chiral gas chromatography (GC) analysis, the selectivity of the cleavage site (a:b) was 1:99, and the optical purity of the crude product was 76% ee.

References

[1] Patent: US6797842, 2004, B2. Location in patent: Page column 19

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL 127733-40-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Career Henan Chemical Co
Product
(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H 127733-40-8
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-02-04

127733-40-8, (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCLRelated Search:

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL (S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL (S)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethylamine (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE (2S)-2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE (1S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]BUTYLAMINE (1S)[3,5-BIS(TRIFLUOROMETHYL)PHENYL]CYCLOPROPYLMETHYLAMINE (1S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-METHYLPROPYLAMINE N1-DI[3,5-DI(TRIFLUOROMETHYL)PHENYL]METHYL-3-BROMOBUTANAMIDE METHYL (3S)-3-AMINO-3-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROPANOATE (S)-2-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)PIPERIDINE (1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2,2,2-TRIFLUOROETHYLAMINE (R)-AMINO-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-ACETIC ACID (R)-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-[(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)]-ACETIC ACID (S)-3-AMINO-3-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID (S)-3-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-3-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID (R)-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-TERT-BUTOXYCARBONYLAMINO-ACETIC ACID

  • (S)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE
  • (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE HCL
  • (S)-ALPHA-METHYL-BIS-3,5-TRIFLUOROMETHYLBENZYLAMINE
  • S-MBT-PEM
  • (S)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHANAMINE
  • (S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE
  • (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-amine
  • (1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine
  • (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride
  • Benzenemethanamine, α-methyl-3,5-bis(trifluoromethyl)-, (αS)-
  • (R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE H
  • (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethan-1-amine
  • 127733-40-8
  • C10H9F6N