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5-Iodoindirubin-3'-monoxime

Product Name
5-Iodoindirubin-3'-monoxime
CAS No.
331467-03-9
Chemical Name
5-Iodoindirubin-3'-monoxime
Synonyms
5-Iodoindirubin-3'-monoxime;5-Iodo-indirubin-3'-monoxime;2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-5-iodo-;Glycogen synthase kinase-3,GSK-3,5Iodoindirubin3'monoxime,CDK,Inhibitor,Glycogen synthase kinase 3,Cyclin dependent kinase,5 Iodo indirubin 3' monoxime,inhibit
CBNumber
CB01115299
Molecular Formula
C16H10IN3O2
Formula Weight
403.17
MOL File
331467-03-9.mol
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5-Iodoindirubin-3'-monoxime Property

Boiling point:
583.3±50.0 °C(Predicted)
Density 
1.99±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 67.5 mg/mL (167.42 mM)
pka
8.52±0.20(Predicted)
form 
Solid
color 
Pink to red
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0094095
Product name
5-Iodo-indirubin-3'-monoxime
Purity
99.50%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0094095
Product name
5-Iodo-indirubin-3'-monoxime
Purity
99.50%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0094095
Product name
5-Iodo-indirubin-3'-monoxime
Purity
99.50%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0094095
Product name
5-Iodo-indirubin-3'-monoxime
Purity
99.50%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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5-Iodoindirubin-3'-monoxime Chemical Properties,Usage,Production

Uses

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

IC 50

GSK-3β: 9 nM (IC50); Cdk5/p25: 20 nM (IC50); Cdk1/cyclin B: 25 nM (IC50)

References

[1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200

5-Iodoindirubin-3'-monoxime Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Iodoindirubin-3'-monoxime Suppliers

China 26 United Kingdom 1 United States 6 Global 33
Shanghai EFE Biological Technology Co., Ltd.
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331467-03-9, 5-Iodoindirubin-3'-monoximeRelated Search:

Dibutyl sebacate

  • 5-Iodoindirubin-3'-monoxime
  • 2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-5-iodo-
  • Glycogen synthase kinase-3,GSK-3,5Iodoindirubin3'monoxime,CDK,Inhibitor,Glycogen synthase kinase 3,Cyclin dependent kinase,5 Iodo indirubin 3' monoxime,inhibit
  • 5-Iodo-indirubin-3'-monoxime
  • 331467-03-9
  • C16H10IN3O2