Boc-(+/-)-trans-2-aminocyclohexanol
- Product Name
- Boc-(+/-)-trans-2-aminocyclohexanol
- CAS No.
- 121282-70-0
- Chemical Name
- Boc-(+/-)-trans-2-aminocyclohexanol
- Synonyms
- 1R,2R-Boc-2-aMinocyclohexanol;trans-N-Boc-2-aminocyclohexanol;tert-Butyl (1R,2R)-2-hydroxycyclohexyl;tert-Butyl (trans-2-hydroxycyclohexyl);tert-butyl (2-hydroxycyclohexyl)carbaMate;Trans-tert-butyl 2-hydroxycyclohexyl)carbaMate;tert-butyl (1R,2R)-2-hydroxycyclohexylcarbamate;tert-Butyl (trans-2-hydroxycyclohexyl)carbaMate;tert-butyl N-[trans-2-hydroxycyclohexyl]carbamate;rel-tert-Butyl N-[(1R,2R)-2-hydroxycyclohexyl]carbamate
- CBNumber
- CB01117011
- Molecular Formula
- C11H21NO3
- Formula Weight
- 215.29
- MOL File
- 121282-70-0.mol
Boc-(+/-)-trans-2-aminocyclohexanol Property
- Boiling point:
- 337.7±31.0 °C(Predicted)
- Density
- 1.06±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.11±0.40(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1/C11H21NO3/c1-11(2,3)15-10(14)12-8-6-4-5-7-9(8)13/h8-9,13H,4-7H2,1-3H3,(H,12,14)/t8-,9-/s3
- InChIKey
- XVROWZPERFUOCE-JQEWEITDNA-N
- SMILES
- C(OC(C)(C)C)(=O)N[C@@H]1CCCC[C@H]1O |&1:8,13,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B810115
- Product name
- tert-ButylN-[(1S,2S)-2-Hydroxycyclohexyl]carbamate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FB140643
- Product name
- tert-Butyl (trans-2-hydroxycyclohexyl)carbamate
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- FB140643
- Product name
- tert-Butyl (trans-2-hydroxycyclohexyl)carbamate
- Packaging
- 2g
- Price
- $129
- Updated
- 2021/12/16
- Product number
- FB140643
- Product name
- tert-Butyl (trans-2-hydroxycyclohexyl)carbamate
- Packaging
- 5G
- Price
- $257
- Updated
- 2021/12/16
- Product number
- Z3986
- Product name
- tert-Butyl(trans-2-hydroxycyclohexyl)carbamate
- Packaging
- 5g
- Price
- $264
- Updated
- 2021/12/16
Boc-(+/-)-trans-2-aminocyclohexanol Chemical Properties,Usage,Production
Uses
tert-Butyl (2-Hydroxycyclohexyl)carbamate is a reagent used in the preparation of N-aryl acetamides from the corresponding nitro compounds.
Synthesis
764659-69-0
121282-70-0
General procedure for the synthesis of trans-N-Boc-cyclohexylamino alcohols from the compounds (CAS: 764659-69-0): the product of part A (8.0 g, 26.2 mmol) was dissolved in a solvent mixture of cyclohexene (100 mL) and ethanol (150 mL), and palladium/carbon catalyst (2.0 g) was added. The reaction mixture was heated to reflux for 6 h. Upon completion of the reaction, the catalyst was removed by filtration through a Celite pad. The filtrate was concentrated to afford tert-butyl (1S,2S)-2-hydroxy-cyclohexyl-carbamate (5.7 g, 100% yield) as a white solid. Mass spectral analysis showed M/Z 216.2 ([M + H]+).
References
[1] Patent: WO2004/83174, 2004, A2. Location in patent: Page 172
[2] Patent: WO2005/87731, 2005, A1. Location in patent: Page/Page column 321
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 16, p. 4419 - 4427
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132
Boc-(+/-)-trans-2-aminocyclohexanol Preparation Products And Raw materials
Raw materials
Preparation Products
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