ChemicalBook > CAS DataBase List > 2-Amino-4-methoxybenzonitrile

2-Amino-4-methoxybenzonitrile

Product Name
2-Amino-4-methoxybenzonitrile
CAS No.
38487-85-3
Chemical Name
2-Amino-4-methoxybenzonitrile
Synonyms
2-Amino-4-methoxybenzonitrile;Benzonitrile, 2-amino-4-methoxy-;2-Amino-4-methoxybenzonitrile ISO 9001：2015 REACH
CBNumber
CB01117420
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
38487-85-3.mol
More
Less

2-Amino-4-methoxybenzonitrile Property

Melting point:
96 °C
Boiling point:
341.5±27.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
1.39±0.10(Predicted)
Appearance
Light yellow to brown Solid
More
Less

Safety

HS Code 
2926907090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
A898648
Product name
2-Amino-4-methoxybenzonitrile
Packaging
250mg
Price
$45
Updated
2021/12/16
Oakwood
Product number
079678
Product name
2-Amino-4-methoxybenzonitrile
Purity
95+%
Packaging
250mg
Price
$18
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA139988
Product name
2-Amino-4-methoxybenzonitrile
Packaging
2g
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-W006163
Product name
2-Amino-4-methoxybenzonitrile
Purity
99.13%
Packaging
5g
Price
$98
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA139988
Product name
2-Amino-4-methoxybenzonitrile
Packaging
5G
Price
$167
Updated
2021/12/16
More
Less

2-Amino-4-methoxybenzonitrile Chemical Properties,Usage,Production

Synthesis

38469-83-9

38487-85-3

The general steps for the synthesis of 2-amino-4-methoxybenzonitrile from 2-nitro-4-methoxybenzonitrile are as follows: 1. Synthesis of intermediate 3: 2-iodo-4-methoxybenzonitrile: 4-methoxy-2-nitrobenzonitrile (5.00 g, 22.46 mmol) was dissolved in ethanol (93 mL) under nitrogen protection and 5% Pd-C (0.500 g) was added. The reaction mixture was subjected to hydrogenation at 1 atm. After 10 hours of reaction, the mixture was filtered through diatomaceous earth and washed with ethyl acetate/methanol. The filtrates were combined and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography using a gradient elution with a hexane solution of 80% to 100% ethyl acetate to give 4-methoxy-2-aminobenzonitrile (3.23 g, 99% yield). 2. 4-Methoxy-2-aminobenzonitrile (1.0 g, 6.58 mmol) was dissolved in a mixed solution of water (7 mL), acetic acid (7 mL) and concentrated hydrochloric acid. Hydrochloric acid was added at room temperature, followed by the slow addition of a solution of sodium nitrite (0.513 g, 7.43 mmol) in water (2 mL) at 0 °C and the reaction was carried out for 5 min. Potassium iodide (2.18 g, 13.2 mmol) was added to the reaction mixture and after stirring at room temperature for 10 h, the reaction mixture was treated with solid sodium bisulfite and diluted with water. The product was extracted with dichloromethane, washed sequentially with saturated sodium bicarbonate solution, brine, the organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using a gradient elution of 10% to 50% ethyl acetate in hexane solution to give the target intermediate (1.0 g, 59% yield).

References

[1] Journal of Organic Chemistry, 2002, vol. 67, # 26, p. 9276 - 9287
[2] Patent: WO2009/65035, 2009, A1. Location in patent: Page/Page column 66-67
[3] Journal of the Chemical Society, 1947, p. 437,44
[4] Journal of the Chemical Society, 1945, p. 861,864

2-Amino-4-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Amino-4-methoxybenzonitrile Suppliers

China 80 India 1 United Kingdom 1 United States 7 Global 89
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
Advantage
60
Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3764
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Jalor-Chem co.,LTD
Tel
0510-0510-86396359 13382276200
Email
sales@jalor-chem.com
Country
China
ProdList
997
Advantage
56
Nanjing ShengSai Chemical Co., Ltd.
Tel
025-85205967 13951876367
Fax
025-85205967
Email
shengsaichem@163.com
Country
China
ProdList
818
Advantage
58
More
Less

View Lastest Price from 2-Amino-4-methoxybenzonitrile manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Amino-4-methoxybenzonitrile 38487-85-3
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-13
Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-4-methoxybenzonitrile 38487-85-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%+
Supply Ability
100 tons
Release date
2020-01-13
Career Henan Chemical Co
Product
2-Amino-4-methoxybenzonitrile 38487-85-3
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-10

38487-85-3, 2-Amino-4-methoxybenzonitrileRelated Search:

2-Amino-4,5-dimethoxybenzonitrile 4,5-DIMETHOXY-2-NITROBENZONITRILE 4-METHOXY-2-NITROBENZONITRILE ETHYL 2-([(2-CYANO-4,5-DIMETHOXYANILINO)CARBOTHIOYL]AMINO)ACETATE N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-CYCLOHEXYLTHIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(4-FLUOROPHENYL)THIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(3,4-DICHLOROBENZYL)THIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-[4-(4-PENTYLCYCLOHEXYL)PHENYL]THIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(2-METHOXYETHYL)THIOUREA 4,5-DIMETHOXY-2-(5-OXO-2-THIOXO-1-IMIDAZOLIDINYL)BENZENECARBONITRILE AKOS B028759 4-AMINO-5-(4-CHLOROBENZOYL)-2-(2-CYANO-4,5-DIMETHOXYANILINO)-3-THIOPHENECARBONITRILE N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(2-METHOXYPHENYL)THIOUREA 3-AMINO-3-[4-(6-CHLORO-2-PYRIDINYL)PIPERAZINO]-2-CYANO-N-(2-CYANO-4,5-DIMETHOXYPHENYL)-2-PROPENETHIOAMIDE N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-(3,5-DIMETHYLPHENYL)THIOUREA N-(2-CYANO-4,5-DIMETHOXYPHENYL)-N'-[3-(TRIFLUOROMETHYL)BENZYL]THIOUREA N-(3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL)-N'-(2-CYANO-4,5-DIMETHOXYPHENYL)THIOUREA 4-[5-CHLORO-1-(3-CHLOROPHENYL)-6-OXO-1,6-DIHYDRO-4-PYRIDAZINYL]-N-(2-CYANO-4,5-DIMETHOXYPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOTHIOAMIDE

  • 2-Amino-4-methoxybenzonitrile
  • Benzonitrile, 2-amino-4-methoxy-
  • 2-Amino-4-methoxybenzonitrile ISO 9001：2015 REACH
  • 38487-85-3