A23187 (MIXED CALCIUM-MAGNESIUM SALT)

A23187 (MIXED CALCIUM-MAGNESIUM SALT) Property

Melting point:

307-311 °C

storage temp. 

2-8°C

solubility 

DMSO: soluble
ethanol: soluble

form 

crystalline solid

color 

yellow

Major Application

diagnostic assay manufacturing
hematology
histology

InChIKey

HKVXGTQLKZNXPV-UHFFFAOYSA-N

SMILES

[Mg++].[Ca++].CNc1ccc2oc(CC3OC4(CCC3C)OC(C(C)CC4C)C(C)C(=O)c5ccc[nH]5)nc2c1C(O)=O

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37

WGK Germany 

3

HS Code 

2941900000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

A23187 (MIXED CALCIUM-MAGNESIUM SALT) Chemical Properties,Usage,Production

Uses

Calcium Ionophore A23187 mixed calcium magnesium salt has been used as a calcium ionophore to increase the intracellular levels of calcium.
Ionophore highly selective for Ca²⁺. Potentiates responses to NMDA but not to quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Biological Activity

Cell permeable: no', 'Primary Target
Useful in cell activation experiments when calcium dose-response data are not required', 'Product does not compete with ATP.', 'Reversible: no